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Aetiology of adenoma--carcinoma sequence in large bowel.
Lancet. 1978 Feb 04; 1(8058):245-7.Lct

Abstract

A hypothesis, based on epidemiological and histopathological data, is proposed to account for the aetiology of colorectal adenomas and carcinomas. Adenomas are initially caused by an environmental agent which acts on the colorectal cells of adenoma-prone persons, a further environmental agent causes small adenomas to grow, and a carcinogen causes malignancy in a high proportion of large adenomas.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

74668

Citation

Hill, M J., et al. "Aetiology of Adenoma--carcinoma Sequence in Large Bowel." Lancet (London, England), vol. 1, no. 8058, 1978, pp. 245-7.
Hill MJ, Morson BC, Bussey HJ. Aetiology of adenoma--carcinoma sequence in large bowel. Lancet. 1978;1(8058):245-7.
Hill, M. J., Morson, B. C., & Bussey, H. J. (1978). Aetiology of adenoma--carcinoma sequence in large bowel. Lancet (London, England), 1(8058), 245-7.
Hill MJ, Morson BC, Bussey HJ. Aetiology of Adenoma--carcinoma Sequence in Large Bowel. Lancet. 1978 Feb 4;1(8058):245-7. PubMed PMID: 74668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aetiology of adenoma--carcinoma sequence in large bowel. AU - Hill,M J, AU - Morson,B C, AU - Bussey,H J, PY - 1978/2/4/pubmed PY - 1978/2/4/medline PY - 1978/2/4/entrez SP - 245 EP - 7 JF - Lancet (London, England) JO - Lancet VL - 1 IS - 8058 N2 - A hypothesis, based on epidemiological and histopathological data, is proposed to account for the aetiology of colorectal adenomas and carcinomas. Adenomas are initially caused by an environmental agent which acts on the colorectal cells of adenoma-prone persons, a further environmental agent causes small adenomas to grow, and a carcinogen causes malignancy in a high proportion of large adenomas. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/74668/Aetiology_of_adenoma__carcinoma_sequence_in_large_bowel_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(78)90487-7 DB - PRIME DP - Unbound Medicine ER -