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COHb formation and acute carbon monoxide intoxication in adult male rats and guinea-pigs.
Bull Eur Physiopathol Respir. 1981 Jan-Feb; 17(1):43-51.BE

Abstract

Respiratory exchange recordings and percentage survivals to lethal concentrations show that rats are more sensitive than guinea-pigs to an acute carbon monoxide intoxication. To avoid circadian respiratory an comportmental differences between rats and guinea-pigs experiments were performed on urethane anesthetized and artificially ventilated animals. This procedure demonstrates that, for an inhaled concentration of 0.05% CO, the rates of formation of COHb do not statistically differ in rats and in guinea-pigs, but that a higher (0.01 less than p less than 0.05) COHb saturation is reached in rats (35%) than in guinea-pigs (25%). For a 2.84% CO inhalation, no statistically significant difference is observed in the rate of COHb formation, but cardiac arrest is sooner (p less than 0.001) observed in rats than in guinea-pigs.

Authors

Stupfel M
No affiliation info available
Mordelet-Dambrine M
No affiliation info available
Vauzelle A
No affiliation info available

MeSH

Acute DiseaseAnestheticsAnimalsCarbon MonoxideCarbon Monoxide PoisoningCarboxyhemoglobinCircadian RhythmGuinea PigsHemoglobinsKineticsMaleRatsRespiration, ArtificialUrethaneVentilation-Perfusion Ratio

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7470685

Citation

Stupfel, M, et al. "COHb Formation and Acute Carbon Monoxide Intoxication in Adult Male Rats and Guinea-pigs." Bulletin Europeen De Physiopathologie Respiratoire, vol. 17, no. 1, 1981, pp. 43-51.
Stupfel M, Mordelet-Dambrine M, Vauzelle A. COHb formation and acute carbon monoxide intoxication in adult male rats and guinea-pigs. Bull Eur Physiopathol Respir. 1981;17(1):43-51.
Stupfel, M., Mordelet-Dambrine, M., & Vauzelle, A. (1981). COHb formation and acute carbon monoxide intoxication in adult male rats and guinea-pigs. Bulletin Europeen De Physiopathologie Respiratoire, 17(1), 43-51.
Stupfel M, Mordelet-Dambrine M, Vauzelle A. COHb Formation and Acute Carbon Monoxide Intoxication in Adult Male Rats and Guinea-pigs. Bull Eur Physiopathol Respir. 1981 Jan-Feb;17(1):43-51. PubMed PMID: 7470685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COHb formation and acute carbon monoxide intoxication in adult male rats and guinea-pigs. AU - Stupfel,M, AU - Mordelet-Dambrine,M, AU - Vauzelle,A, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 43 EP - 51 JF - Bulletin europeen de physiopathologie respiratoire JO - Bull Eur Physiopathol Respir VL - 17 IS - 1 N2 - Respiratory exchange recordings and percentage survivals to lethal concentrations show that rats are more sensitive than guinea-pigs to an acute carbon monoxide intoxication. To avoid circadian respiratory an comportmental differences between rats and guinea-pigs experiments were performed on urethane anesthetized and artificially ventilated animals. This procedure demonstrates that, for an inhaled concentration of 0.05% CO, the rates of formation of COHb do not statistically differ in rats and in guinea-pigs, but that a higher (0.01 less than p less than 0.05) COHb saturation is reached in rats (35%) than in guinea-pigs (25%). For a 2.84% CO inhalation, no statistically significant difference is observed in the rate of COHb formation, but cardiac arrest is sooner (p less than 0.001) observed in rats than in guinea-pigs. SN - 0395-3890 UR - https://www.unboundmedicine.com/medline/citation/7470685/COHb_formation_and_acute_carbon_monoxide_intoxication_in_adult_male_rats_and_guinea_pigs_ DB - PRIME DP - Unbound Medicine ER -