Tags

Type your tag names separated by a space and hit enter

Epidemiology of uterine leiomyomas. With an etiologic hypothesis.
J Reprod Med 1995; 40(8):595-600JR

Abstract

OBJECTIVE

The few previous epidemiologic studies of uterine myomas have relied on clinical evaluation to select controls, but we previously showed that myomas may be present in more than 75% of such uteri.

STUDY DESIGN

We therefore attempted to evaluate risk factors using age-matched controls whose uteri were serially sectioned to exclude the presence of myomas.

RESULTS

The small study size precluded a meaningful evaluation of most parameters but tended to confirm the negative association of myomas with cigarette smoking (P = .07).

CONCLUSION

Using monoclonal smooth muscle proliferation in human atherosclerotic plaques as a model, we suggest that excessive injury to and repair of the endometrial lining of the uterus may promote monoclonal expansion of smooth muscle cell populations in the uterine wall (i.e., myomas). This theory is largely compatible with the estrogen hypothesis, but fundamental principles of tumorigenesis and previous epidemiologic data on myomas suggest that nutritional factors should be scrutinized as possible initiators (DNA-damaging substances) in the pathogenesis of uterine myomas.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Rochester General Hospital, New York, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7473458

Citation

Cramer, S F., et al. "Epidemiology of Uterine Leiomyomas. With an Etiologic Hypothesis." The Journal of Reproductive Medicine, vol. 40, no. 8, 1995, pp. 595-600.
Cramer SF, Horiszny JA, Leppert P. Epidemiology of uterine leiomyomas. With an etiologic hypothesis. J Reprod Med. 1995;40(8):595-600.
Cramer, S. F., Horiszny, J. A., & Leppert, P. (1995). Epidemiology of uterine leiomyomas. With an etiologic hypothesis. The Journal of Reproductive Medicine, 40(8), pp. 595-600.
Cramer SF, Horiszny JA, Leppert P. Epidemiology of Uterine Leiomyomas. With an Etiologic Hypothesis. J Reprod Med. 1995;40(8):595-600. PubMed PMID: 7473458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of uterine leiomyomas. With an etiologic hypothesis. AU - Cramer,S F, AU - Horiszny,J A, AU - Leppert,P, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 595 EP - 600 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 40 IS - 8 N2 - OBJECTIVE: The few previous epidemiologic studies of uterine myomas have relied on clinical evaluation to select controls, but we previously showed that myomas may be present in more than 75% of such uteri. STUDY DESIGN: We therefore attempted to evaluate risk factors using age-matched controls whose uteri were serially sectioned to exclude the presence of myomas. RESULTS: The small study size precluded a meaningful evaluation of most parameters but tended to confirm the negative association of myomas with cigarette smoking (P = .07). CONCLUSION: Using monoclonal smooth muscle proliferation in human atherosclerotic plaques as a model, we suggest that excessive injury to and repair of the endometrial lining of the uterus may promote monoclonal expansion of smooth muscle cell populations in the uterine wall (i.e., myomas). This theory is largely compatible with the estrogen hypothesis, but fundamental principles of tumorigenesis and previous epidemiologic data on myomas suggest that nutritional factors should be scrutinized as possible initiators (DNA-damaging substances) in the pathogenesis of uterine myomas. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/7473458/Epidemiology_of_uterine_leiomyomas__With_an_etiologic_hypothesis_ L2 - https://medlineplus.gov/uterinefibroids.html DB - PRIME DP - Unbound Medicine ER -