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Development of a rat model for iron deficiency and toxicological studies: comparison among Fischer 344, Wistar, and Sprague Dawley strains.
Lab Anim Sci 1995; 45(4):393-7LA

Abstract

We carried out a comparative study to develop iron deficiency in three strains of rats: Fischer 344, Wistar, and Sprague Dawley. Considering that certain ingredients in the diet, such as sucrose, may inhibit enzymes of drug metabolism, which we planned to study during an iron deficiency state, the diet was modified to contain 35% each of sucrose and starch. Results of hematologic studies at the end of 6 weeks of iron deprivation clearly indicated that all clinical signs of iron deficiency anemia--hemoglobin concentration, protoporphyrin-to-heme ratio, and serum and liver iron concentrations--were affected in the three strains. However, the deficiency was less pronounced in Sprague Dawley than in Wistar and Fischer 344 strains. Results of this study suggest that rat strains respond differently to dietary iron inadequacy; this variability could be exploited to suit specific experimental needs.

Authors+Show Affiliations

Food and Drug Toxicology Research Centre, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7474878

Citation

Rao, J, and V Jagadeesan. "Development of a Rat Model for Iron Deficiency and Toxicological Studies: Comparison Among Fischer 344, Wistar, and Sprague Dawley Strains." Laboratory Animal Science, vol. 45, no. 4, 1995, pp. 393-7.
Rao J, Jagadeesan V. Development of a rat model for iron deficiency and toxicological studies: comparison among Fischer 344, Wistar, and Sprague Dawley strains. Lab Anim Sci. 1995;45(4):393-7.
Rao, J., & Jagadeesan, V. (1995). Development of a rat model for iron deficiency and toxicological studies: comparison among Fischer 344, Wistar, and Sprague Dawley strains. Laboratory Animal Science, 45(4), pp. 393-7.
Rao J, Jagadeesan V. Development of a Rat Model for Iron Deficiency and Toxicological Studies: Comparison Among Fischer 344, Wistar, and Sprague Dawley Strains. Lab Anim Sci. 1995;45(4):393-7. PubMed PMID: 7474878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of a rat model for iron deficiency and toxicological studies: comparison among Fischer 344, Wistar, and Sprague Dawley strains. AU - Rao,J, AU - Jagadeesan,V, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 393 EP - 7 JF - Laboratory animal science JO - Lab. Anim. Sci. VL - 45 IS - 4 N2 - We carried out a comparative study to develop iron deficiency in three strains of rats: Fischer 344, Wistar, and Sprague Dawley. Considering that certain ingredients in the diet, such as sucrose, may inhibit enzymes of drug metabolism, which we planned to study during an iron deficiency state, the diet was modified to contain 35% each of sucrose and starch. Results of hematologic studies at the end of 6 weeks of iron deprivation clearly indicated that all clinical signs of iron deficiency anemia--hemoglobin concentration, protoporphyrin-to-heme ratio, and serum and liver iron concentrations--were affected in the three strains. However, the deficiency was less pronounced in Sprague Dawley than in Wistar and Fischer 344 strains. Results of this study suggest that rat strains respond differently to dietary iron inadequacy; this variability could be exploited to suit specific experimental needs. SN - 0023-6764 UR - https://www.unboundmedicine.com/medline/citation/7474878/Development_of_a_rat_model_for_iron_deficiency_and_toxicological_studies:_comparison_among_Fischer_344_Wistar_and_Sprague_Dawley_strains_ L2 - https://medlineplus.gov/iron.html DB - PRIME DP - Unbound Medicine ER -