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[Characteristics of HLA II antigen expression in the rectal mucosa of children suffering form ulcerative colitis and Crohn disease].
Orv Hetil. 1995 Oct 15; 136(42):2279-82.OH

Abstract

The staining of HLA class II. antigens was studied with monoclonal antibodies using sensitive immunohistochemical methods in the rectal biopsy specimens taken from 4 children with Crohn's disease and 9 with ulcerative colitis as well as from 10 controls. HLA class II. antigen expression was not seen in the surface and crypt epithelium of controls. The majority of patients showed epithelial HLA-DR, and HLA-DP expression, fewer had HLA-DQ expression. In patients who had more severe clinical and histological symptoms the epithelial HLA-DR and HLA-DP expression was more intense, than in those with milder presentation (p < 0.05). We conclude that the activity of ulcerative colitis may be infered from the intensity of HLA class II. antigen expression.

Authors+Show Affiliations

Semmelweis Orvostudományi Egyetem I. sz. Gyermekklinika.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

hun

PubMed ID

7478471

Citation

Hacsek, G, et al. "[Characteristics of HLA II Antigen Expression in the Rectal Mucosa of Children Suffering Form Ulcerative Colitis and Crohn Disease]." Orvosi Hetilap, vol. 136, no. 42, 1995, pp. 2279-82.
Hacsek G, Arató A, Savilahti E, et al. [Characteristics of HLA II antigen expression in the rectal mucosa of children suffering form ulcerative colitis and Crohn disease]. Orv Hetil. 1995;136(42):2279-82.
Hacsek, G., Arató, A., Savilahti, E., & Pászti, I. (1995). [Characteristics of HLA II antigen expression in the rectal mucosa of children suffering form ulcerative colitis and Crohn disease]. Orvosi Hetilap, 136(42), 2279-82.
Hacsek G, et al. [Characteristics of HLA II Antigen Expression in the Rectal Mucosa of Children Suffering Form Ulcerative Colitis and Crohn Disease]. Orv Hetil. 1995 Oct 15;136(42):2279-82. PubMed PMID: 7478471.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Characteristics of HLA II antigen expression in the rectal mucosa of children suffering form ulcerative colitis and Crohn disease]. AU - Hacsek,G, AU - Arató,A, AU - Savilahti,E, AU - Pászti,I, PY - 1995/10/15/pubmed PY - 1995/10/15/medline PY - 1995/10/15/entrez SP - 2279 EP - 82 JF - Orvosi hetilap JO - Orv Hetil VL - 136 IS - 42 N2 - The staining of HLA class II. antigens was studied with monoclonal antibodies using sensitive immunohistochemical methods in the rectal biopsy specimens taken from 4 children with Crohn's disease and 9 with ulcerative colitis as well as from 10 controls. HLA class II. antigen expression was not seen in the surface and crypt epithelium of controls. The majority of patients showed epithelial HLA-DR, and HLA-DP expression, fewer had HLA-DQ expression. In patients who had more severe clinical and histological symptoms the epithelial HLA-DR and HLA-DP expression was more intense, than in those with milder presentation (p < 0.05). We conclude that the activity of ulcerative colitis may be infered from the intensity of HLA class II. antigen expression. SN - 0030-6002 UR - https://www.unboundmedicine.com/medline/citation/7478471/[Characteristics_of_HLA_II_antigen_expression_in_the_rectal_mucosa_of_children_suffering_form_ulcerative_colitis_and_Crohn_disease]_ L2 - http://www.diseaseinfosearch.org/result/7285 DB - PRIME DP - Unbound Medicine ER -