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Growth hormone modulation of arginine-induced glucagon release: studies of isolated growth hormone deficiency and acromegaly.
Clin Endocrinol (Oxf). 1978 Dec; 9(6):563-70.CE

Abstract

Plasma glucagon and insulin responses to L-arginine were compared in normal controls and patients with isolated growth hormone deficiency and acromegaly. Patients with isolated growth hormone deficiency were characterized by high plasma glucagon response and low plasma insulin response, whereas acromegalic patients showed exaggerated plasma glucagon response and almost normal insulin response. These results suggest that growth hormone is probably required for optimum function of the islets, and since hyperglucagonaemia was observed in both growth hormone deficiency and acromegaly, metabolic disturbances stemming from the respective primary diseases may affect glucagon secretion.

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Authors

Seino Y
No affiliation info available
Taminato T
No affiliation info available
Goto Y
No affiliation info available
Inoue Y
No affiliation info available
Kadowaki S
No affiliation info available
Hattori M
No affiliation info available
Mori K
No affiliation info available
Kato Y
No affiliation info available
Matsukura S
No affiliation info available
Imura H
No affiliation info available

MeSH

AcromegalyAdolescentAdultArginineBlood GlucoseChildDiabetes MellitusFemaleGlucagonGrowth HormoneHumansInsulinMaleMiddle Aged

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

747897

Citation

Seino, Y, et al. "Growth Hormone Modulation of Arginine-induced Glucagon Release: Studies of Isolated Growth Hormone Deficiency and Acromegaly." Clinical Endocrinology, vol. 9, no. 6, 1978, pp. 563-70.
Seino Y, Taminato T, Goto Y, et al. Growth hormone modulation of arginine-induced glucagon release: studies of isolated growth hormone deficiency and acromegaly. Clin Endocrinol (Oxf). 1978;9(6):563-70.
Seino, Y., Taminato, T., Goto, Y., Inoue, Y., Kadowaki, S., Hattori, M., Mori, K., Kato, Y., Matsukura, S., & Imura, H. (1978). Growth hormone modulation of arginine-induced glucagon release: studies of isolated growth hormone deficiency and acromegaly. Clinical Endocrinology, 9(6), 563-70.
Seino Y, et al. Growth Hormone Modulation of Arginine-induced Glucagon Release: Studies of Isolated Growth Hormone Deficiency and Acromegaly. Clin Endocrinol (Oxf). 1978;9(6):563-70. PubMed PMID: 747897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Growth hormone modulation of arginine-induced glucagon release: studies of isolated growth hormone deficiency and acromegaly. AU - Seino,Y, AU - Taminato,T, AU - Goto,Y, AU - Inoue,Y, AU - Kadowaki,S, AU - Hattori,M, AU - Mori,K, AU - Kato,Y, AU - Matsukura,S, AU - Imura,H, PY - 1978/12/1/pubmed PY - 1978/12/1/medline PY - 1978/12/1/entrez SP - 563 EP - 70 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 9 IS - 6 N2 - Plasma glucagon and insulin responses to L-arginine were compared in normal controls and patients with isolated growth hormone deficiency and acromegaly. Patients with isolated growth hormone deficiency were characterized by high plasma glucagon response and low plasma insulin response, whereas acromegalic patients showed exaggerated plasma glucagon response and almost normal insulin response. These results suggest that growth hormone is probably required for optimum function of the islets, and since hyperglucagonaemia was observed in both growth hormone deficiency and acromegaly, metabolic disturbances stemming from the respective primary diseases may affect glucagon secretion. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/747897/Growth_hormone_modulation_of_arginine_induced_glucagon_release:_studies_of_isolated_growth_hormone_deficiency_and_acromegaly_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0300-0664&date=1978&volume=9&issue=6&spage=563 DB - PRIME DP - Unbound Medicine ER -