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Maternal Lyme disease and congenital malformations: a cord blood serosurvey in endemic and control areas.

Abstract

This report describes a cohort study of over 5000 infants and their mothers who participated in a cord blood serosurvey designed to examine the relationship between maternal exposure to Lyme disease and adverse pregnancy outcome. Based on serology and reported clinical history, mothers of infants in an endemic hospital cohort are 5 to 20 times more likely to have been exposed to B. burgdorferi as compared with mothers of infants in a control hospital cohort. The incidence of total congenital malformations was not significantly different in the endemic cohort compared with the control cohort, but the rate of cardiac malformations was significantly higher in the endemic cohort [odds ratio (OR) 2.40; 95% confidence interval (CI) 1.25, 4.59] and the frequencies of certain minor malformations (haemangiomas, polydactyly, and hydrocele), were significantly increased in the control group. Demographic variations could only account for differences in the frequency of polydactyly. Within the endemic cohort, there were no differences in the rate of major or minor malformations or mean birthweight by category of possible maternal exposure to Lyme disease or cord blood serology. The disparity between observations at the population and individual levels requires further investigation. The absence of association at the individual level in the endemic area could be because of the small number of women who were actually exposed either in terms of serology or clinical history. The reason for the findings at the population level is not known but could be because of artifact or population differences.

Authors

, , , ,

Source

MeSH

Adult
Animals
Bites and Stings
Borrelia burgdorferi Group
Case-Control Studies
Chi-Square Distribution
Congenital Abnormalities
Enzyme-Linked Immunosorbent Assay
Female
Fetal Blood
Follow-Up Studies
Heart Defects, Congenital
Humans
Incidence
Infant
Lyme Disease
New York
Odds Ratio
Pregnancy
Pregnancy Complications, Infectious
Prevalence
Ticks

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7479280

Citation

TY - JOUR T1 - Maternal Lyme disease and congenital malformations: a cord blood serosurvey in endemic and control areas. AU - Williams,C L, AU - Strobino,B, AU - Weinstein,A, AU - Spierling,P, AU - Medici,F, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 320 EP - 30 JF - Paediatric and perinatal epidemiology JO - Paediatr Perinat Epidemiol VL - 9 IS - 3 N2 - This report describes a cohort study of over 5000 infants and their mothers who participated in a cord blood serosurvey designed to examine the relationship between maternal exposure to Lyme disease and adverse pregnancy outcome. Based on serology and reported clinical history, mothers of infants in an endemic hospital cohort are 5 to 20 times more likely to have been exposed to B. burgdorferi as compared with mothers of infants in a control hospital cohort. The incidence of total congenital malformations was not significantly different in the endemic cohort compared with the control cohort, but the rate of cardiac malformations was significantly higher in the endemic cohort [odds ratio (OR) 2.40; 95% confidence interval (CI) 1.25, 4.59] and the frequencies of certain minor malformations (haemangiomas, polydactyly, and hydrocele), were significantly increased in the control group. Demographic variations could only account for differences in the frequency of polydactyly. Within the endemic cohort, there were no differences in the rate of major or minor malformations or mean birthweight by category of possible maternal exposure to Lyme disease or cord blood serology. The disparity between observations at the population and individual levels requires further investigation. The absence of association at the individual level in the endemic area could be because of the small number of women who were actually exposed either in terms of serology or clinical history. The reason for the findings at the population level is not known but could be because of artifact or population differences. SN - 0269-5022 UR - https://www.unboundmedicine.com/medline/citation/7479280/abstract/Maternal_Lyme_disease_and_congenital_malformations:_a_cord_blood_serosurvey_in_endemic_and_control_areas_ L2 - http://www.scholaruniverse.com/ncbi-linkout?id=7479280 ER -