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Intestinal calcium absorption as shown by stable strontium test in celiac disease before and after gluten-free diet.
Am J Gastroenterol. 1995 Nov; 90(11):2025-8.AJ

Abstract

OBJECTIVES

To investigate the effect of gluten-free diet on mineral and bone metabolism in women with celiac disease and, using the strontium test, to assess intestinal calcium absorption.

METHODS

We studied body mass index, biochemical and bone mineral indices, strontium absorption test, and bone mineral density in 18 women (mean age 36.8 yr, range 18-68 yr) with celiac disease at diagnosis and after 12 months of gluten-free diet.

RESULTS

Mean strontium absorption at diagnosis was markedly decreased with respect to control values (13.84 +/- 9.03% vs 22.47 +/- 4.21%, p < 0.0001), and 11 of the 18 patients (61%, subgroup A) had low values. In all patients, mean hemoglobin, serum potassium, magnesium, plasma calcium, urinary calcium, and phosphorus were significantly abnormal at diagnosis, whereas only the subgroup A had significantly reduced body mass index, 25 OH vitamin D, and elevated alkaline phosphatase. This subgroup differed in body mass index (p < 0.003) and calciuria (p < 0.035) with respect to the other patients. Strontium absorption correlated with body mass index, calcemia, and 25 OH vitamin D. After the gluten-free diet, all biochemical variables and strontium absorption normalized (23.23 +/- 5.54%), whereas bone mineral density did not change.

CONCLUSIONS

At diagnosis, the patients frequently had intestinal calcium malabsorption, as demonstrated by strontium test, with an early renal compensatory mechanism. After the gluten-free diet, the normalization of calcium absorption and the decrease of mid-molecule parathyroid hormone suggested a normalization of mineral metabolism, although a positive effect on bone mineral density was not evident at that time.

Authors+Show Affiliations

Cattedra di Gastroenterologia, University of Milan, IRCCS Ospedale Maggiore, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7485015

Citation

Molteni, N, et al. "Intestinal Calcium Absorption as Shown By Stable Strontium Test in Celiac Disease Before and After Gluten-free Diet." The American Journal of Gastroenterology, vol. 90, no. 11, 1995, pp. 2025-8.
Molteni N, Bardella MT, Vezzoli G, et al. Intestinal calcium absorption as shown by stable strontium test in celiac disease before and after gluten-free diet. Am J Gastroenterol. 1995;90(11):2025-8.
Molteni, N., Bardella, M. T., Vezzoli, G., Pozzoli, E., & Bianchi, P. (1995). Intestinal calcium absorption as shown by stable strontium test in celiac disease before and after gluten-free diet. The American Journal of Gastroenterology, 90(11), 2025-8.
Molteni N, et al. Intestinal Calcium Absorption as Shown By Stable Strontium Test in Celiac Disease Before and After Gluten-free Diet. Am J Gastroenterol. 1995;90(11):2025-8. PubMed PMID: 7485015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intestinal calcium absorption as shown by stable strontium test in celiac disease before and after gluten-free diet. AU - Molteni,N, AU - Bardella,M T, AU - Vezzoli,G, AU - Pozzoli,E, AU - Bianchi,P, PY - 1995/11/1/pubmed PY - 1995/11/1/medline PY - 1995/11/1/entrez SP - 2025 EP - 8 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 90 IS - 11 N2 - OBJECTIVES: To investigate the effect of gluten-free diet on mineral and bone metabolism in women with celiac disease and, using the strontium test, to assess intestinal calcium absorption. METHODS: We studied body mass index, biochemical and bone mineral indices, strontium absorption test, and bone mineral density in 18 women (mean age 36.8 yr, range 18-68 yr) with celiac disease at diagnosis and after 12 months of gluten-free diet. RESULTS: Mean strontium absorption at diagnosis was markedly decreased with respect to control values (13.84 +/- 9.03% vs 22.47 +/- 4.21%, p < 0.0001), and 11 of the 18 patients (61%, subgroup A) had low values. In all patients, mean hemoglobin, serum potassium, magnesium, plasma calcium, urinary calcium, and phosphorus were significantly abnormal at diagnosis, whereas only the subgroup A had significantly reduced body mass index, 25 OH vitamin D, and elevated alkaline phosphatase. This subgroup differed in body mass index (p < 0.003) and calciuria (p < 0.035) with respect to the other patients. Strontium absorption correlated with body mass index, calcemia, and 25 OH vitamin D. After the gluten-free diet, all biochemical variables and strontium absorption normalized (23.23 +/- 5.54%), whereas bone mineral density did not change. CONCLUSIONS: At diagnosis, the patients frequently had intestinal calcium malabsorption, as demonstrated by strontium test, with an early renal compensatory mechanism. After the gluten-free diet, the normalization of calcium absorption and the decrease of mid-molecule parathyroid hormone suggested a normalization of mineral metabolism, although a positive effect on bone mineral density was not evident at that time. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/7485015/Intestinal_calcium_absorption_as_shown_by_stable_strontium_test_in_celiac_disease_before_and_after_gluten_free_diet_ L2 - http://www.diseaseinfosearch.org/result/1186 DB - PRIME DP - Unbound Medicine ER -