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Prevalence of hepatitis C antibody in patients with chronic liver disease and hepatocellular carcinoma in Korea.
J Viral Hepat 1995; 2(4):195-202JV

Abstract

To investigate the contribution of hepatitis C virus (HCV) to chronic liver disease and hepatocellular carcinoma (HCC) in Korea, antibodies to HCV (anti-HCV) were tested by enzyme immunoassay in 1759 patients with chronic liver disease and HCC, and in 808 healthy adults. The prevalence of anti-HCV was 1.6% in 808 controls. Anti-HCV was present in 32 (7.7%) of 418 hepatitis B surface antigen (HBsAg)-positive and 128 (53.1%) of 241 HBsAg-negative patients with chronic hepatitis, 16 (6.0%) of 265 HBsAg-positive and 90 (30.5%) of 295 HBsAg-negative patients with liver cirrhosis, and 16 (4.8%) of 330 HBsAg-positive and 61 (29.0%) of 210 HBsAg-negative patients with HCC. Antibodies to hepatitis B core antigen (anti-HBc) were present in 80-88% of patients who were seropositive for anti-HCV and seronegative for HBsAg. Among the sera from 114 patients with HBsAg-negative and anti-HCV-positive chronic liver diseases, HBV DNA and HCV RNA were detected by polymerase chain reaction (PCR) in 54 (47.4%) and 61 (53.3%), respectively. Both HBV DNA and HCV RNA were detected in 4 (4.4%) samples. The mean age of the patients with both HBsAg and anti-HCV was not different from that of patients who were seropositive for HBsAg alone. These findings indicate that current and/or past HBV infection is still the main cause of chronic liver disease in Korea.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Kosin Cancer Research Institute, Kosin University School of Medicine, Pusan, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7489347

Citation

Park, B C., et al. "Prevalence of Hepatitis C Antibody in Patients With Chronic Liver Disease and Hepatocellular Carcinoma in Korea." Journal of Viral Hepatitis, vol. 2, no. 4, 1995, pp. 195-202.
Park BC, Han BH, Ahn SY, et al. Prevalence of hepatitis C antibody in patients with chronic liver disease and hepatocellular carcinoma in Korea. J Viral Hepat. 1995;2(4):195-202.
Park, B. C., Han, B. H., Ahn, S. Y., Lee, S. W., Lee, D. H., Lee, Y. N., ... Kim, K. W. (1995). Prevalence of hepatitis C antibody in patients with chronic liver disease and hepatocellular carcinoma in Korea. Journal of Viral Hepatitis, 2(4), pp. 195-202.
Park BC, et al. Prevalence of Hepatitis C Antibody in Patients With Chronic Liver Disease and Hepatocellular Carcinoma in Korea. J Viral Hepat. 1995;2(4):195-202. PubMed PMID: 7489347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of hepatitis C antibody in patients with chronic liver disease and hepatocellular carcinoma in Korea. AU - Park,B C, AU - Han,B H, AU - Ahn,S Y, AU - Lee,S W, AU - Lee,D H, AU - Lee,Y N, AU - Seo,J H, AU - Kim,K W, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 195 EP - 202 JF - Journal of viral hepatitis JO - J. Viral Hepat. VL - 2 IS - 4 N2 - To investigate the contribution of hepatitis C virus (HCV) to chronic liver disease and hepatocellular carcinoma (HCC) in Korea, antibodies to HCV (anti-HCV) were tested by enzyme immunoassay in 1759 patients with chronic liver disease and HCC, and in 808 healthy adults. The prevalence of anti-HCV was 1.6% in 808 controls. Anti-HCV was present in 32 (7.7%) of 418 hepatitis B surface antigen (HBsAg)-positive and 128 (53.1%) of 241 HBsAg-negative patients with chronic hepatitis, 16 (6.0%) of 265 HBsAg-positive and 90 (30.5%) of 295 HBsAg-negative patients with liver cirrhosis, and 16 (4.8%) of 330 HBsAg-positive and 61 (29.0%) of 210 HBsAg-negative patients with HCC. Antibodies to hepatitis B core antigen (anti-HBc) were present in 80-88% of patients who were seropositive for anti-HCV and seronegative for HBsAg. Among the sera from 114 patients with HBsAg-negative and anti-HCV-positive chronic liver diseases, HBV DNA and HCV RNA were detected by polymerase chain reaction (PCR) in 54 (47.4%) and 61 (53.3%), respectively. Both HBV DNA and HCV RNA were detected in 4 (4.4%) samples. The mean age of the patients with both HBsAg and anti-HCV was not different from that of patients who were seropositive for HBsAg alone. These findings indicate that current and/or past HBV infection is still the main cause of chronic liver disease in Korea.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 1352-0504 UR - https://www.unboundmedicine.com/medline/citation/7489347/Prevalence_of_hepatitis_C_antibody_in_patients_with_chronic_liver_disease_and_hepatocellular_carcinoma_in_Korea_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1352-0504&date=1995&volume=2&issue=4&spage=195 DB - PRIME DP - Unbound Medicine ER -