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Immunoglobulin M antibody to hepatitis C virus core antigen: correlations with viral replication, histological activity, and liver disease outcome.
Hepatology. 1995 Dec; 22(6):1635-40.Hep

Abstract

Immunoglobulin M (IgM) antibody to hepatitis C core antigen (anti-HCV-core) was tested by enzyme immunoassay against a synthetic peptide representing amino acids 1 to 62 of the core protein. Of 214 patients with different categories of histological activity, 193 (90%) showed positive results for IgM anti-HCV-core, and 207 (97%) had HCV RNA; most cases (186, 87%) had both markers detectable simultaneously. No differences in the frequency of IgM anti-HCV-core were observed with respect to epidemiological, biochemical, or histological parameters. In 175 interferon alfa (IFN-alpha) recipients, and in 39 untreated controls, pretreatment IgM anti-HCV-core frequencies were similar: 28 of 32 (88%) in sustained responders; 55 of 61 (90%) in responders with relapse; 72 of 82 (88%) in nonresponders; and 38 of 39 (97%) in untreated controls. After IFN-alpha therapy, IgM anti-HCV-core levels became undetectable with significantly greater frequency in sustained responders (P = .014); a similar trend was observed for HCV RNA (P < .0001). IgM anti-HCV-core levels decreased after therapy in responders (P < .001) but increased in nonresponders. Fifty-one cases were longitudinally tested in relation to long-term disease outcome. Both markers remained detectable in most nonresponders with persistent liver disease, in most responders before relapse, and in all but one case at the time of biochemical relapse. IgM anti-HCV-core and HCV RNA became undetectable in most sustained responders, but reappeared despite a long-lasting transaminase normalization, behaving as asymptomatic HCV carriers; the possibility that disease reactivation may take place years afterwards cannot be excluded.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Hepatology Unit, Fundación Jiménez Díaz, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7489967

Citation

Quiroga, J A., et al. "Immunoglobulin M Antibody to Hepatitis C Virus Core Antigen: Correlations With Viral Replication, Histological Activity, and Liver Disease Outcome." Hepatology (Baltimore, Md.), vol. 22, no. 6, 1995, pp. 1635-40.
Quiroga JA, van Binsbergen J, Wang CY, et al. Immunoglobulin M antibody to hepatitis C virus core antigen: correlations with viral replication, histological activity, and liver disease outcome. Hepatology. 1995;22(6):1635-40.
Quiroga, J. A., van Binsbergen, J., Wang, C. Y., Pardo, M., Navas, S., Trines, C., Herrero, M., & Carreño, V. (1995). Immunoglobulin M antibody to hepatitis C virus core antigen: correlations with viral replication, histological activity, and liver disease outcome. Hepatology (Baltimore, Md.), 22(6), 1635-40.
Quiroga JA, et al. Immunoglobulin M Antibody to Hepatitis C Virus Core Antigen: Correlations With Viral Replication, Histological Activity, and Liver Disease Outcome. Hepatology. 1995;22(6):1635-40. PubMed PMID: 7489967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoglobulin M antibody to hepatitis C virus core antigen: correlations with viral replication, histological activity, and liver disease outcome. AU - Quiroga,J A, AU - van Binsbergen,J, AU - Wang,C Y, AU - Pardo,M, AU - Navas,S, AU - Trines,C, AU - Herrero,M, AU - Carreño,V, PY - 1995/12/1/pubmed PY - 1995/12/1/medline PY - 1995/12/1/entrez SP - 1635 EP - 40 JF - Hepatology (Baltimore, Md.) JO - Hepatology VL - 22 IS - 6 N2 - Immunoglobulin M (IgM) antibody to hepatitis C core antigen (anti-HCV-core) was tested by enzyme immunoassay against a synthetic peptide representing amino acids 1 to 62 of the core protein. Of 214 patients with different categories of histological activity, 193 (90%) showed positive results for IgM anti-HCV-core, and 207 (97%) had HCV RNA; most cases (186, 87%) had both markers detectable simultaneously. No differences in the frequency of IgM anti-HCV-core were observed with respect to epidemiological, biochemical, or histological parameters. In 175 interferon alfa (IFN-alpha) recipients, and in 39 untreated controls, pretreatment IgM anti-HCV-core frequencies were similar: 28 of 32 (88%) in sustained responders; 55 of 61 (90%) in responders with relapse; 72 of 82 (88%) in nonresponders; and 38 of 39 (97%) in untreated controls. After IFN-alpha therapy, IgM anti-HCV-core levels became undetectable with significantly greater frequency in sustained responders (P = .014); a similar trend was observed for HCV RNA (P < .0001). IgM anti-HCV-core levels decreased after therapy in responders (P < .001) but increased in nonresponders. Fifty-one cases were longitudinally tested in relation to long-term disease outcome. Both markers remained detectable in most nonresponders with persistent liver disease, in most responders before relapse, and in all but one case at the time of biochemical relapse. IgM anti-HCV-core and HCV RNA became undetectable in most sustained responders, but reappeared despite a long-lasting transaminase normalization, behaving as asymptomatic HCV carriers; the possibility that disease reactivation may take place years afterwards cannot be excluded.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0270-9139 UR - https://www.unboundmedicine.com/medline/citation/7489967/Immunoglobulin_M_antibody_to_hepatitis_C_virus_core_antigen:_correlations_with_viral_replication_histological_activity_and_liver_disease_outcome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0270913995004162 DB - PRIME DP - Unbound Medicine ER -