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[The value of the parathyrin-related protein (PTH-RP) in the diagnosis of cancer-associated hypercalcemia].
Med Clin (Barc). 1995 Oct 14; 105(12):450-4.MC

Abstract

BACKGROUND

The parathyrine related protein (PTH-RP) is very similar, both in structure and in function, to the PTH and is considered as a mediator in humoral hypercalcemia in cancer. The aim of this study was to know the clinical value of PTH-RP measurement.

METHODS

Serum PTH-RP concentrations were studied in 22 healthy subjects, 13 patients with primary hyperparathyroidism, 9 patients with solid neoplasms and normocalcemia, 26 patients with solid neoplasms and hypercalcemia and 4 patients with hematologic neoplasms and hypercalcemia. The PTH-RP was quantified by a competitive radioimmunoassay technique using a specific antibody of the PTH-RP 1-40 fragment. Intact parathyrine (i-PTH) was quantified by an IRMA method using 2 polyclonal antibodies (INCSTAR).

RESULTS

Fifteen (68%) of the healthy controls presented undetectable serum PTH-RP concentrations. The serum PTH-RP concentration was normal in all those patients with hyperparathyroidism. Elevated serum PTH-RP values were not found in patients with solid neoplasms and normocalcemia or in those with hematologic neoplasms and hypercalcemia. High values of PTH-RP were observed in 8 out of 9 (88%) of the patients with solid neoplasms and hypercalcemia with bone metastasis and in 7 out of 11 (63%) of the patients with bone involvement.

CONCLUSIONS

Serum parathyrine-related protein was found to be high in a large proportion of patients with solid neoplasms and hypercalcemia. Serum PTH-RP determination is useful in the clinical investigation of patients with hypercalcemia. Even in patients with bone metastasis, hypercalcemia may have a humoral background.

Authors+Show Affiliations

Sagarra E
Servicio de Endocrinología, Ciutat Sanitària i Universitària de Bellvitge, L'Hospitalet de Llobregat, Barcelona.
Villabona C
No affiliation info available
Bonnin R
No affiliation info available
Moliner R
No affiliation info available
Merino FJ
No affiliation info available
Sahún M
No affiliation info available
Soler J
No affiliation info available

MeSH

AdultAgedBiomarkersFemaleHumansHypercalcemiaImmunoradiometric AssayMaleMiddle AgedNeoplasm ProteinsNeoplasmsParathyroid HormoneParathyroid Hormone-Related ProteinProteinsRadioimmunoassayStatistics, Nonparametric

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

spa

PubMed ID

7490935

Citation

Sagarra, E, et al. "[The Value of the Parathyrin-related Protein (PTH-RP) in the Diagnosis of Cancer-associated Hypercalcemia]." Medicina Clinica, vol. 105, no. 12, 1995, pp. 450-4.
Sagarra E, Villabona C, Bonnin R, et al. [The value of the parathyrin-related protein (PTH-RP) in the diagnosis of cancer-associated hypercalcemia]. Med Clin (Barc). 1995;105(12):450-4.
Sagarra, E., Villabona, C., Bonnin, R., Moliner, R., Merino, F. J., Sahún, M., & Soler, J. (1995). [The value of the parathyrin-related protein (PTH-RP) in the diagnosis of cancer-associated hypercalcemia]. Medicina Clinica, 105(12), 450-4.
Sagarra E, et al. [The Value of the Parathyrin-related Protein (PTH-RP) in the Diagnosis of Cancer-associated Hypercalcemia]. Med Clin (Barc). 1995 Oct 14;105(12):450-4. PubMed PMID: 7490935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The value of the parathyrin-related protein (PTH-RP) in the diagnosis of cancer-associated hypercalcemia]. AU - Sagarra,E, AU - Villabona,C, AU - Bonnin,R, AU - Moliner,R, AU - Merino,F J, AU - Sahún,M, AU - Soler,J, PY - 1995/10/14/pubmed PY - 1995/10/14/medline PY - 1995/10/14/entrez SP - 450 EP - 4 JF - Medicina clinica JO - Med Clin (Barc) VL - 105 IS - 12 N2 - BACKGROUND: The parathyrine related protein (PTH-RP) is very similar, both in structure and in function, to the PTH and is considered as a mediator in humoral hypercalcemia in cancer. The aim of this study was to know the clinical value of PTH-RP measurement. METHODS: Serum PTH-RP concentrations were studied in 22 healthy subjects, 13 patients with primary hyperparathyroidism, 9 patients with solid neoplasms and normocalcemia, 26 patients with solid neoplasms and hypercalcemia and 4 patients with hematologic neoplasms and hypercalcemia. The PTH-RP was quantified by a competitive radioimmunoassay technique using a specific antibody of the PTH-RP 1-40 fragment. Intact parathyrine (i-PTH) was quantified by an IRMA method using 2 polyclonal antibodies (INCSTAR). RESULTS: Fifteen (68%) of the healthy controls presented undetectable serum PTH-RP concentrations. The serum PTH-RP concentration was normal in all those patients with hyperparathyroidism. Elevated serum PTH-RP values were not found in patients with solid neoplasms and normocalcemia or in those with hematologic neoplasms and hypercalcemia. High values of PTH-RP were observed in 8 out of 9 (88%) of the patients with solid neoplasms and hypercalcemia with bone metastasis and in 7 out of 11 (63%) of the patients with bone involvement. CONCLUSIONS: Serum parathyrine-related protein was found to be high in a large proportion of patients with solid neoplasms and hypercalcemia. Serum PTH-RP determination is useful in the clinical investigation of patients with hypercalcemia. Even in patients with bone metastasis, hypercalcemia may have a humoral background. SN - 0025-7753 UR - https://www.unboundmedicine.com/medline/citation/7490935/[The_value_of_the_parathyrin_related_protein__PTH_RP__in_the_diagnosis_of_cancer_associated_hypercalcemia]_ L2 - https://antibodies.cancer.gov/detail/CPTC-PTHrP-1 DB - PRIME DP - Unbound Medicine ER -