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Urinary lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets.
Nutr Cancer. 1995; 24(1):1-12.NC

Abstract

Urinary lignan and isoflavonoid excretion were examined in 11 men and 9 women consuming four nine-day controlled experimental diets: basal (vegetable free), carotenoid vegetable (carrot and spinach), cruciferous vegetable (broccoli and cauliflower), and soy (tofu and textured vegetable protein product). Three-day urine collections (Days 7-9) were analyzed for lignans and isoflavonoids with use of isotope-dilution gas chromatography-mass spectrometry. Urinary excretion of the lignans enterodiol and enterolactone was higher during the carotenoid and cruciferous vegetable diets than during the basal diet (p = 0.0001), suggesting that these vegetables may provide a source of mammalian lignan precursors. Urinary excretion of the isoflavonoids equol, O-desmethylangolensin, daidzein, and genistein was higher when subjects consumed soy diets than when they consumed the other test diets (p < 0.02). Gender differences in lignan excretion were observed. Men excreted more enterolactone (p = 0.006) and less enterodiol (p = 0.013) than women, implying a gender difference in colonic bacterial metabolism of lignans. There was no effect of gender on isoflavonoid excretion.

Authors+Show Affiliations

Department of Food Science and Nutrition, University of Minnesota, St. Paul 55108-6099, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7491293

Citation

Kirkman, L M., et al. "Urinary Lignan and Isoflavonoid Excretion in Men and Women Consuming Vegetable and Soy Diets." Nutrition and Cancer, vol. 24, no. 1, 1995, pp. 1-12.
Kirkman LM, Lampe JW, Campbell DR, et al. Urinary lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets. Nutr Cancer. 1995;24(1):1-12.
Kirkman, L. M., Lampe, J. W., Campbell, D. R., Martini, M. C., & Slavin, J. L. (1995). Urinary lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets. Nutrition and Cancer, 24(1), 1-12.
Kirkman LM, et al. Urinary Lignan and Isoflavonoid Excretion in Men and Women Consuming Vegetable and Soy Diets. Nutr Cancer. 1995;24(1):1-12. PubMed PMID: 7491293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets. AU - Kirkman,L M, AU - Lampe,J W, AU - Campbell,D R, AU - Martini,M C, AU - Slavin,J L, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 1 EP - 12 JF - Nutrition and cancer JO - Nutr Cancer VL - 24 IS - 1 N2 - Urinary lignan and isoflavonoid excretion were examined in 11 men and 9 women consuming four nine-day controlled experimental diets: basal (vegetable free), carotenoid vegetable (carrot and spinach), cruciferous vegetable (broccoli and cauliflower), and soy (tofu and textured vegetable protein product). Three-day urine collections (Days 7-9) were analyzed for lignans and isoflavonoids with use of isotope-dilution gas chromatography-mass spectrometry. Urinary excretion of the lignans enterodiol and enterolactone was higher during the carotenoid and cruciferous vegetable diets than during the basal diet (p = 0.0001), suggesting that these vegetables may provide a source of mammalian lignan precursors. Urinary excretion of the isoflavonoids equol, O-desmethylangolensin, daidzein, and genistein was higher when subjects consumed soy diets than when they consumed the other test diets (p < 0.02). Gender differences in lignan excretion were observed. Men excreted more enterolactone (p = 0.006) and less enterodiol (p = 0.013) than women, implying a gender difference in colonic bacterial metabolism of lignans. There was no effect of gender on isoflavonoid excretion. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/7491293/Urinary_lignan_and_isoflavonoid_excretion_in_men_and_women_consuming_vegetable_and_soy_diets_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635589509514388 DB - PRIME DP - Unbound Medicine ER -