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The tar reduction study: randomised trial of the effect of cigarette tar yield reduction on compensatory smoking.
Thorax. 1995 Oct; 50(10):1038-43.T

Abstract

BACKGROUND

Observational and short term intervention studies have reported that smokers of low tar cigarettes inhale more deeply (that is, compensate) than those who smoke high tar cigarettes. To quantify this effect a long term randomised trial was conducted on the effects of switching to low tar cigarettes.

METHODS

The trial was carried out between April 1985 and March 1988 among cigarette smokers in the British Civil Service, measuring blood carboxyhaemoglobin (COHb) levels and serum cotinine levels as markers of tobacco smoke intake. Volunteers first switched to a cigarette brand yielding around 10% less tar than their usual brand to identify smokers able to change brand. The 434 subjects who successfully switched were then randomly allocated to one of three groups: (a) "fast reduction" group which changed to a brand of cigarettes with a tar yield of about half that of their usual brand; (b) "slow reduction" group which reduced to the same level in steps over several months; and (c) a control group which continued smoking cigarettes with a tar yield 10% lower than their usual brand.

RESULTS

Over the course of the trial cigarette consumption declined slightly in all three groups. In both the "fast reduction" and the "slow reduction" groups, intake of COHb and cotinine was reduced, though not to the same extent as the yield reduction. Comparison of the results before randomisation with those at the end of the trial showed that a reduction in carbon monoxide yield of 45% was associated with a decrease in carbon monoxide intake of 19% (95% confidence interval 14% to 24%) and that a reduction in nicotine yield of 40% was associated with an 11% (6% to 16%) reduction in nicotine intake, reflecting relative intakes of about 1.5 for both carbon monoxide and nicotine in the "fast reduction" group. Results were similar in the "slow reduction" group with a 42% reduction in carbon monoxide yield, a 16% (11% to 22%) reduction in carbon monoxide intake, a 37% reduction in nicotine yield, and a 6% (0% to 13%) reduction in nicotine intake. Estimates of compensation derived from these results were 65% for carbon monoxide, 79% for nicotine, and 62% for tar.

CONCLUSIONS

Compensation, demonstrated when switching from a high tar cigarette to a low tar one, was incomplete. Advising people who have failed to give up smoking to switch to low tar cigarettes will reduce the intake of smoke constituents to a small extent. This would be expected to decrease their risk of smoking-related diseases, although by a smaller amount than would be achieved by giving up smoking altogether.

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Authors+Show Affiliations

Frost C
Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew's Hospital Medical College, London, UK.
Fullerton FM
No affiliation info available
Stephen AM
No affiliation info available
Stone R
No affiliation info available
Nicolaides-Bouman A
No affiliation info available
Densem J
No affiliation info available
Wald NJ
No affiliation info available
Semmence A
No affiliation info available

MeSH

Adaptation, PsychologicalCarboxyhemoglobinCotinineFemaleHumansMalePlants, ToxicSmokingTarsTobacco

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7491550

Citation

Frost, C, et al. "The Tar Reduction Study: Randomised Trial of the Effect of Cigarette Tar Yield Reduction On Compensatory Smoking." Thorax, vol. 50, no. 10, 1995, pp. 1038-43.
Frost C, Fullerton FM, Stephen AM, et al. The tar reduction study: randomised trial of the effect of cigarette tar yield reduction on compensatory smoking. Thorax. 1995;50(10):1038-43.
Frost, C., Fullerton, F. M., Stephen, A. M., Stone, R., Nicolaides-Bouman, A., Densem, J., Wald, N. J., & Semmence, A. (1995). The tar reduction study: randomised trial of the effect of cigarette tar yield reduction on compensatory smoking. Thorax, 50(10), 1038-43.
Frost C, et al. The Tar Reduction Study: Randomised Trial of the Effect of Cigarette Tar Yield Reduction On Compensatory Smoking. Thorax. 1995;50(10):1038-43. PubMed PMID: 7491550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The tar reduction study: randomised trial of the effect of cigarette tar yield reduction on compensatory smoking. AU - Frost,C, AU - Fullerton,F M, AU - Stephen,A M, AU - Stone,R, AU - Nicolaides-Bouman,A, AU - Densem,J, AU - Wald,N J, AU - Semmence,A, PY - 1995/10/1/pubmed PY - 1995/10/1/medline PY - 1995/10/1/entrez SP - 1038 EP - 43 JF - Thorax JO - Thorax VL - 50 IS - 10 N2 - BACKGROUND: Observational and short term intervention studies have reported that smokers of low tar cigarettes inhale more deeply (that is, compensate) than those who smoke high tar cigarettes. To quantify this effect a long term randomised trial was conducted on the effects of switching to low tar cigarettes. METHODS: The trial was carried out between April 1985 and March 1988 among cigarette smokers in the British Civil Service, measuring blood carboxyhaemoglobin (COHb) levels and serum cotinine levels as markers of tobacco smoke intake. Volunteers first switched to a cigarette brand yielding around 10% less tar than their usual brand to identify smokers able to change brand. The 434 subjects who successfully switched were then randomly allocated to one of three groups: (a) "fast reduction" group which changed to a brand of cigarettes with a tar yield of about half that of their usual brand; (b) "slow reduction" group which reduced to the same level in steps over several months; and (c) a control group which continued smoking cigarettes with a tar yield 10% lower than their usual brand. RESULTS: Over the course of the trial cigarette consumption declined slightly in all three groups. In both the "fast reduction" and the "slow reduction" groups, intake of COHb and cotinine was reduced, though not to the same extent as the yield reduction. Comparison of the results before randomisation with those at the end of the trial showed that a reduction in carbon monoxide yield of 45% was associated with a decrease in carbon monoxide intake of 19% (95% confidence interval 14% to 24%) and that a reduction in nicotine yield of 40% was associated with an 11% (6% to 16%) reduction in nicotine intake, reflecting relative intakes of about 1.5 for both carbon monoxide and nicotine in the "fast reduction" group. Results were similar in the "slow reduction" group with a 42% reduction in carbon monoxide yield, a 16% (11% to 22%) reduction in carbon monoxide intake, a 37% reduction in nicotine yield, and a 6% (0% to 13%) reduction in nicotine intake. Estimates of compensation derived from these results were 65% for carbon monoxide, 79% for nicotine, and 62% for tar. CONCLUSIONS: Compensation, demonstrated when switching from a high tar cigarette to a low tar one, was incomplete. Advising people who have failed to give up smoking to switch to low tar cigarettes will reduce the intake of smoke constituents to a small extent. This would be expected to decrease their risk of smoking-related diseases, although by a smaller amount than would be achieved by giving up smoking altogether. SN - 0040-6376 UR - https://www.unboundmedicine.com/medline/citation/7491550/The_tar_reduction_study:_randomised_trial_of_the_effect_of_cigarette_tar_yield_reduction_on_compensatory_smoking_ L2 - https://thorax.bmj.com/lookup/pmidlookup?view=long&pmid=7491550 DB - PRIME DP - Unbound Medicine ER -