Tags

Type your tag names separated by a space and hit enter

Comparison of fluticasone propionate and beclomethasone dipropionate on direct and indirect measurements of bronchial hyperresponsiveness in patients with stable asthma.
Thorax. 1995 Oct; 50(10):1044-50.T

Abstract

BACKGROUND

Fluticasone propionate is a new inhaled corticosteroid with a 2:1 efficacy ratio compared with beclomethasone dipropionate with regard to lung function and symptom scores, without increased systemic activity. The aim of this study was to investigate whether this was also the case for bronchial hyperresponsiveness, assessed by both a direct (histamine) and an indirect (ultrasonically nebulised distilled water (UNDW)) provocation test.

METHODS

Fluticasone propionate, 750 micrograms/day, and beclomethasone dipropionate, 1500 micrograms/day, were compared in a randomised, double blind, crossover study consisting of two six week treatment periods, each preceded by a three week single blind placebo period. Twenty one non-smoking asthmatics (mean forced expiratory volume in one second (FEV1) 74.7% predicted, mean PC20histamine 0.36 mg/ml) completed the study.

RESULTS

Fluticasone propionate and beclomethasone dipropionate improved FEV1, peak flow rates, asthma symptoms, and bronchial hyperresponsiveness to the same extent. Both fluticasone propionate and beclomethasone dipropionate caused an increase in PC20histamine (mean 2.29 [95% confidence interval 1.45 to 3.13] and 1.95 [1.07 to 2.84] doubling doses, respectively) and in PD20UNDW (1.12 [0.55 to 1.70] and 1.28 [0.88 to 1.70] doubling doses, respectively). Neither treatment changed morning serum cortisol levels, but fluticasone propionate decreased the number of peripheral blood eosinophils less than beclomethasone dipropionate, indicating smaller systemic effects of fluticasone propionate.

CONCLUSIONS

These findings show that fluticasone propionate is as effective as twice the dose of beclomethasone dipropionate on bronchial hyperresponsiveness, assessed by provocation with both histamine and UNDW, without increased systemic activity.

Authors+Show Affiliations

Department of Pulmonary Diseases, University Hospital, Nijmegen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7491551

Citation

Bootsma, G P., et al. "Comparison of Fluticasone Propionate and Beclomethasone Dipropionate On Direct and Indirect Measurements of Bronchial Hyperresponsiveness in Patients With Stable Asthma." Thorax, vol. 50, no. 10, 1995, pp. 1044-50.
Bootsma GP, Dekhuijzen PN, Festen J, et al. Comparison of fluticasone propionate and beclomethasone dipropionate on direct and indirect measurements of bronchial hyperresponsiveness in patients with stable asthma. Thorax. 1995;50(10):1044-50.
Bootsma, G. P., Dekhuijzen, P. N., Festen, J., Mulder, P. G., & van Herwaarden, C. L. (1995). Comparison of fluticasone propionate and beclomethasone dipropionate on direct and indirect measurements of bronchial hyperresponsiveness in patients with stable asthma. Thorax, 50(10), 1044-50.
Bootsma GP, et al. Comparison of Fluticasone Propionate and Beclomethasone Dipropionate On Direct and Indirect Measurements of Bronchial Hyperresponsiveness in Patients With Stable Asthma. Thorax. 1995;50(10):1044-50. PubMed PMID: 7491551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of fluticasone propionate and beclomethasone dipropionate on direct and indirect measurements of bronchial hyperresponsiveness in patients with stable asthma. AU - Bootsma,G P, AU - Dekhuijzen,P N, AU - Festen,J, AU - Mulder,P G, AU - van Herwaarden,C L, PY - 1995/10/1/pubmed PY - 1995/10/1/medline PY - 1995/10/1/entrez SP - 1044 EP - 50 JF - Thorax JO - Thorax VL - 50 IS - 10 N2 - BACKGROUND: Fluticasone propionate is a new inhaled corticosteroid with a 2:1 efficacy ratio compared with beclomethasone dipropionate with regard to lung function and symptom scores, without increased systemic activity. The aim of this study was to investigate whether this was also the case for bronchial hyperresponsiveness, assessed by both a direct (histamine) and an indirect (ultrasonically nebulised distilled water (UNDW)) provocation test. METHODS: Fluticasone propionate, 750 micrograms/day, and beclomethasone dipropionate, 1500 micrograms/day, were compared in a randomised, double blind, crossover study consisting of two six week treatment periods, each preceded by a three week single blind placebo period. Twenty one non-smoking asthmatics (mean forced expiratory volume in one second (FEV1) 74.7% predicted, mean PC20histamine 0.36 mg/ml) completed the study. RESULTS: Fluticasone propionate and beclomethasone dipropionate improved FEV1, peak flow rates, asthma symptoms, and bronchial hyperresponsiveness to the same extent. Both fluticasone propionate and beclomethasone dipropionate caused an increase in PC20histamine (mean 2.29 [95% confidence interval 1.45 to 3.13] and 1.95 [1.07 to 2.84] doubling doses, respectively) and in PD20UNDW (1.12 [0.55 to 1.70] and 1.28 [0.88 to 1.70] doubling doses, respectively). Neither treatment changed morning serum cortisol levels, but fluticasone propionate decreased the number of peripheral blood eosinophils less than beclomethasone dipropionate, indicating smaller systemic effects of fluticasone propionate. CONCLUSIONS: These findings show that fluticasone propionate is as effective as twice the dose of beclomethasone dipropionate on bronchial hyperresponsiveness, assessed by provocation with both histamine and UNDW, without increased systemic activity. SN - 0040-6376 UR - https://www.unboundmedicine.com/medline/citation/7491551/Comparison_of_fluticasone_propionate_and_beclomethasone_dipropionate_on_direct_and_indirect_measurements_of_bronchial_hyperresponsiveness_in_patients_with_stable_asthma_ L2 - http://thorax.bmj.com/cgi/pmidlookup?view=long&pmid=7491551 DB - PRIME DP - Unbound Medicine ER -