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Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of very old patients.

Abstract

OBJECTIVES

To examine the correlations between senile lesion densities and development of dementia symptoms in very old people. To perform a quantitative neuropathologic evaluation of several cortical and subcortical areas in a series of 29 nonagenarians and centenarians.

PATIENTS

Ten patients with no cognitive impairment and 19 patients with clinically overt Alzheimer's disease.

DESIGN

Neuropathologic case series. Severity of Alzheimer's disease was assessed with the Mini-Mental State examination and by postmortem chart review using the extended Clinical Dementia Rating Scale. Comparisons between neurofibrillary tangle and senile plaque densities in demented and nondemented individuals were performed by analysis of covariance controlling for age at the time of death.

SETTING

Studies were conducted at the Psychiatric and Geriatric hospitals of the University of Geneva School of Medicine in Geneva, Switzerland.

MAIN OUTCOME MEASURE

Correlations between clinical diagnosis and severity of Alzheimer's disease and neuropathologic change densities.

RESULTS

Statistically significant differences were found in neurofibrillary tangle densities in the superior parietal, superior temporal, anterior and posterior cingulate cortex, and nucleus basalis of Meynert between nondemented and Alzheimer's disease cases. The superior parietal and posterior cingulate cortex contained significantly higher senile plaque counts in demented compared with nondemented cases. In contrast to younger demented cases, the number of senile plaques in the neocortex was correlated with the severity of dementia in centenarians.

CONCLUSIONS

These results indicate that the neuronal degeneration in very old demented patients involves cortical areas usually preserved at the early stages of the dementing process. Senile plaque formation in certain neocortical areas may be a pathologic hallmark of the severity of dementia in this particular age group.

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  • Authors+Show Affiliations

    ,

    Department of Psychiatry, University of Geneva School of Medicine, Switzerland.

    , , , ,

    Source

    Archives of neurology 52:12 1995 Dec pg 1150-9

    MeSH

    Aged
    Aged, 80 and over
    Aging
    Alzheimer Disease
    Analysis of Variance
    Cerebral Cortex
    Female
    Humans
    Male
    Neurofibrillary Tangles

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    7492288

    Citation

    Giannakopoulos, P, et al. "Regional Distribution of Neurofibrillary Tangles and Senile Plaques in the Cerebral Cortex of Very Old Patients." Archives of Neurology, vol. 52, no. 12, 1995, pp. 1150-9.
    Giannakopoulos P, Hof PR, Giannakopoulos AS, et al. Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of very old patients. Arch Neurol. 1995;52(12):1150-9.
    Giannakopoulos, P., Hof, P. R., Giannakopoulos, A. S., Herrmann, F. R., Michel, J. P., & Bouras, C. (1995). Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of very old patients. Archives of Neurology, 52(12), pp. 1150-9.
    Giannakopoulos P, et al. Regional Distribution of Neurofibrillary Tangles and Senile Plaques in the Cerebral Cortex of Very Old Patients. Arch Neurol. 1995;52(12):1150-9. PubMed PMID: 7492288.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of very old patients. AU - Giannakopoulos,P, AU - Hof,P R, AU - Giannakopoulos,A S, AU - Herrmann,F R, AU - Michel,J P, AU - Bouras,C, PY - 1995/12/1/pubmed PY - 1995/12/1/medline PY - 1995/12/1/entrez SP - 1150 EP - 9 JF - Archives of neurology JO - Arch. Neurol. VL - 52 IS - 12 N2 - OBJECTIVES: To examine the correlations between senile lesion densities and development of dementia symptoms in very old people. To perform a quantitative neuropathologic evaluation of several cortical and subcortical areas in a series of 29 nonagenarians and centenarians. PATIENTS: Ten patients with no cognitive impairment and 19 patients with clinically overt Alzheimer's disease. DESIGN: Neuropathologic case series. Severity of Alzheimer's disease was assessed with the Mini-Mental State examination and by postmortem chart review using the extended Clinical Dementia Rating Scale. Comparisons between neurofibrillary tangle and senile plaque densities in demented and nondemented individuals were performed by analysis of covariance controlling for age at the time of death. SETTING: Studies were conducted at the Psychiatric and Geriatric hospitals of the University of Geneva School of Medicine in Geneva, Switzerland. MAIN OUTCOME MEASURE: Correlations between clinical diagnosis and severity of Alzheimer's disease and neuropathologic change densities. RESULTS: Statistically significant differences were found in neurofibrillary tangle densities in the superior parietal, superior temporal, anterior and posterior cingulate cortex, and nucleus basalis of Meynert between nondemented and Alzheimer's disease cases. The superior parietal and posterior cingulate cortex contained significantly higher senile plaque counts in demented compared with nondemented cases. In contrast to younger demented cases, the number of senile plaques in the neocortex was correlated with the severity of dementia in centenarians. CONCLUSIONS: These results indicate that the neuronal degeneration in very old demented patients involves cortical areas usually preserved at the early stages of the dementing process. Senile plaque formation in certain neocortical areas may be a pathologic hallmark of the severity of dementia in this particular age group. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/7492288/Regional_distribution_of_neurofibrillary_tangles_and_senile_plaques_in_the_cerebral_cortex_of_very_old_patients_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/vol/52/pg/1150 DB - PRIME DP - Unbound Medicine ER -