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Alteration in the frequency, severity and duration of chemotherapy-induced mucositis in hamsters by interleukin-11.
Eur J Cancer B Oral Oncol 1995; 31B(4):261-6EJ

Abstract

Ninety-five young, male Golden Syrian hamsters were randomly divided into five equally sized groups. One group served as a placebo control while the animals in the others received one of four doses of interleukin-eleven (IL-11) twice daily given by subcutaneous injection beginning on the first day of chemotherapy (day 0) and continuing to day 14. Mucositis was induced with 5-fluorouracil using a standard regimen of 60 mg/kg, intraperitoneally on days 0 and 2 followed by superficial mucosal irritation on day 4. Animals were evaluated daily beginning on day 6. Mucositis was assessed using a standardised technique in which randomly numbered daily mucosal photographs were scored by three blinded independent observers at the conclusion of the experiment. IL-11 favourably affected the frequency, severity and duration of mucositis. This phenomenon appeared to be dose dependent. Hamsters receiving 30 and 100 micrograms per day of IL-11 demonstrated significantly (P < 0.05) lower mucositis scores than did either the control or animals receiving 3 or 10 micrograms per day, although the latter had marginal beneficial effects. Additionally, survival was significantly better for hamsters receiving higher doses of IL-11 (85%) compared to the placebo control (46%). IL-11 administration also favourably affected weight loss. While stimulation of platelet production was noted in animals receiving IL-11, a lack of difference in bone marrow cellularity between test and control animals suggests that the mechanism by which IL-11 modifies mucositis is mediated at the epithelial or connective tissue level rather than through the marrow. The kinetics of IL-11 alteration of mucositis induction supports such a hypothesis. Further investigation is currently underway to establish a definitive mechanism by which IL-11 protects the oral mucosa.

Authors+Show Affiliations

Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, Massachusetts, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7492924

Citation

Sonis, S, et al. "Alteration in the Frequency, Severity and Duration of Chemotherapy-induced Mucositis in Hamsters By Interleukin-11." European Journal of Cancer. Part B, Oral Oncology, vol. 31B, no. 4, 1995, pp. 261-6.
Sonis S, Muska A, O'Brien J, et al. Alteration in the frequency, severity and duration of chemotherapy-induced mucositis in hamsters by interleukin-11. Eur J Cancer, B, Oral Oncol. 1995;31B(4):261-6.
Sonis, S., Muska, A., O'Brien, J., Van Vugt, A., Langer-Safer, P., & Keith, J. (1995). Alteration in the frequency, severity and duration of chemotherapy-induced mucositis in hamsters by interleukin-11. European Journal of Cancer. Part B, Oral Oncology, 31B(4), pp. 261-6.
Sonis S, et al. Alteration in the Frequency, Severity and Duration of Chemotherapy-induced Mucositis in Hamsters By Interleukin-11. Eur J Cancer, B, Oral Oncol. 1995;31B(4):261-6. PubMed PMID: 7492924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alteration in the frequency, severity and duration of chemotherapy-induced mucositis in hamsters by interleukin-11. AU - Sonis,S, AU - Muska,A, AU - O'Brien,J, AU - Van Vugt,A, AU - Langer-Safer,P, AU - Keith,J, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 261 EP - 6 JF - European journal of cancer. Part B, Oral oncology JO - Eur. J. Cancer, B, Oral Oncol. VL - 31B IS - 4 N2 - Ninety-five young, male Golden Syrian hamsters were randomly divided into five equally sized groups. One group served as a placebo control while the animals in the others received one of four doses of interleukin-eleven (IL-11) twice daily given by subcutaneous injection beginning on the first day of chemotherapy (day 0) and continuing to day 14. Mucositis was induced with 5-fluorouracil using a standard regimen of 60 mg/kg, intraperitoneally on days 0 and 2 followed by superficial mucosal irritation on day 4. Animals were evaluated daily beginning on day 6. Mucositis was assessed using a standardised technique in which randomly numbered daily mucosal photographs were scored by three blinded independent observers at the conclusion of the experiment. IL-11 favourably affected the frequency, severity and duration of mucositis. This phenomenon appeared to be dose dependent. Hamsters receiving 30 and 100 micrograms per day of IL-11 demonstrated significantly (P < 0.05) lower mucositis scores than did either the control or animals receiving 3 or 10 micrograms per day, although the latter had marginal beneficial effects. Additionally, survival was significantly better for hamsters receiving higher doses of IL-11 (85%) compared to the placebo control (46%). IL-11 administration also favourably affected weight loss. While stimulation of platelet production was noted in animals receiving IL-11, a lack of difference in bone marrow cellularity between test and control animals suggests that the mechanism by which IL-11 modifies mucositis is mediated at the epithelial or connective tissue level rather than through the marrow. The kinetics of IL-11 alteration of mucositis induction supports such a hypothesis. Further investigation is currently underway to establish a definitive mechanism by which IL-11 protects the oral mucosa. SN - 0964-1955 UR - https://www.unboundmedicine.com/medline/citation/7492924/Alteration_in_the_frequency_severity_and_duration_of_chemotherapy_induced_mucositis_in_hamsters_by_interleukin_11_ L2 - https://www.lens.org/lens/search?q=citation_id:7492924 DB - PRIME DP - Unbound Medicine ER -