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Simultaneous determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in human hair by gas chromatography-mass spectrometry.
J Chromatogr B Biomed Appl. 1995 Aug 04; 670(1):162-6.JC

Abstract

A procedure is presented for the simultaneous identification and quantification of amphetamine (AP), methamphetamine (MA), methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) in human hair. The method involves decontamination of hair with dichloromethane and warm water, heat-alkaline hydrolysis in the presence of deuterated internal standards, liquid-liquid extraction and gas chromatography-mass spectrometry after derivatization with pentafluoropropionic anhydride-pentafluoropropanol. The limit of detection for AP, MA and MDA was 0.05 ng/mg using a 50-mg hair sample; for MDMA it was 0.1 ng/mg. Coefficients of variation ranged from 7 to 18%. This assay has been successfully utilized in the evaluation of the deposition of the drugs in hair obtained from various parts of the anatomy of a stimulant abuser.

Authors+Show Affiliations

Institut de Médecine Légale, Strasbourg, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7493075

Citation

Kintz, P, et al. "Simultaneous Determination of Amphetamine, Methamphetamine, 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in Human Hair By Gas Chromatography-mass Spectrometry." Journal of Chromatography. B, Biomedical Applications, vol. 670, no. 1, 1995, pp. 162-6.
Kintz P, Cirimele V, Tracqui A, et al. Simultaneous determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in human hair by gas chromatography-mass spectrometry. J Chromatogr B, Biomed Appl. 1995;670(1):162-6.
Kintz, P., Cirimele, V., Tracqui, A., & Mangin, P. (1995). Simultaneous determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in human hair by gas chromatography-mass spectrometry. Journal of Chromatography. B, Biomedical Applications, 670(1), 162-6.
Kintz P, et al. Simultaneous Determination of Amphetamine, Methamphetamine, 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in Human Hair By Gas Chromatography-mass Spectrometry. J Chromatogr B, Biomed Appl. 1995 Aug 4;670(1):162-6. PubMed PMID: 7493075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in human hair by gas chromatography-mass spectrometry. AU - Kintz,P, AU - Cirimele,V, AU - Tracqui,A, AU - Mangin,P, PY - 1995/8/4/pubmed PY - 1995/8/4/medline PY - 1995/8/4/entrez SP - 162 EP - 6 JF - Journal of chromatography. B, Biomedical applications JO - J. Chromatogr. B, Biomed. Appl. VL - 670 IS - 1 N2 - A procedure is presented for the simultaneous identification and quantification of amphetamine (AP), methamphetamine (MA), methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) in human hair. The method involves decontamination of hair with dichloromethane and warm water, heat-alkaline hydrolysis in the presence of deuterated internal standards, liquid-liquid extraction and gas chromatography-mass spectrometry after derivatization with pentafluoropropionic anhydride-pentafluoropropanol. The limit of detection for AP, MA and MDA was 0.05 ng/mg using a 50-mg hair sample; for MDMA it was 0.1 ng/mg. Coefficients of variation ranged from 7 to 18%. This assay has been successfully utilized in the evaluation of the deposition of the drugs in hair obtained from various parts of the anatomy of a stimulant abuser. SN - 1572-6495 UR - https://www.unboundmedicine.com/medline/citation/7493075/Simultaneous_determination_of_amphetamine_methamphetamine_34_methylenedioxyamphetamine_and_34_methylenedioxymethamphetamine_in_human_hair_by_gas_chromatography_mass_spectrometry_ L2 - https://medlineplus.gov/clubdrugs.html DB - PRIME DP - Unbound Medicine ER -