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Genetic determinants of plasma factor VII activity in the Japanese.
Thromb Haemost. 1995 Apr; 73(4):617-22.TH

Abstract

We investigated the frequency of the factor VII Gln353 (FVII Gln353) allele in Japan, where coronary artery disease is much less common and factor VII coagulant activity (FVIIc) is lower than in Western countries. Japanese males (n = 144) aged 40-59 years living in 2 different districts were studied, and the FVIIc and activated factor VII (FVIIa) levels were measured with human (FVIIa Hum) and bovine soluble tissue factor (FVIIa Bov). The frequency of the FVII Gln353 allele in the 2 districts was 0.026 and 0.052 (combined: 0.034), which was about one third of that in a European population. Thus, the lower FVIIc level in Japanese is not due to the effect of FVII Gln353 allele. Ten individuals with the Gln353 allele showed a 39% decrease of FVIIa Hum levels and a 29% decrease of the FVIIa Bov level compared with 134 individuals homozygous for the FVII Arg353 allele. These decreases of FVIIa were greater than the decrease of FVIIc (17%), suggesting that FVII Gln353 may be difficult to activate in vivo. The marked decrease of FVIIa levels in individuals with the FVII Gln353 allele suggests that they are genetically protected against cardiovascular disease irrespective of ethnic background, by virtue of their decreased FVIIa level.

Authors+Show Affiliations

Department of Internal Medicine, Awaji-Hokudan Public Clinic, Hyogo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7495068

Citation

Kario, K, et al. "Genetic Determinants of Plasma Factor VII Activity in the Japanese." Thrombosis and Haemostasis, vol. 73, no. 4, 1995, pp. 617-22.
Kario K, Narita N, Matsuo T, et al. Genetic determinants of plasma factor VII activity in the Japanese. Thromb Haemost. 1995;73(4):617-22.
Kario, K., Narita, N., Matsuo, T., Kayaba, K., Tsutsumi, A., Matsuo, M., Miyata, T., & Shimada, K. (1995). Genetic determinants of plasma factor VII activity in the Japanese. Thrombosis and Haemostasis, 73(4), 617-22.
Kario K, et al. Genetic Determinants of Plasma Factor VII Activity in the Japanese. Thromb Haemost. 1995;73(4):617-22. PubMed PMID: 7495068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic determinants of plasma factor VII activity in the Japanese. AU - Kario,K, AU - Narita,N, AU - Matsuo,T, AU - Kayaba,K, AU - Tsutsumi,A, AU - Matsuo,M, AU - Miyata,T, AU - Shimada,K, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez SP - 617 EP - 22 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 73 IS - 4 N2 - We investigated the frequency of the factor VII Gln353 (FVII Gln353) allele in Japan, where coronary artery disease is much less common and factor VII coagulant activity (FVIIc) is lower than in Western countries. Japanese males (n = 144) aged 40-59 years living in 2 different districts were studied, and the FVIIc and activated factor VII (FVIIa) levels were measured with human (FVIIa Hum) and bovine soluble tissue factor (FVIIa Bov). The frequency of the FVII Gln353 allele in the 2 districts was 0.026 and 0.052 (combined: 0.034), which was about one third of that in a European population. Thus, the lower FVIIc level in Japanese is not due to the effect of FVII Gln353 allele. Ten individuals with the Gln353 allele showed a 39% decrease of FVIIa Hum levels and a 29% decrease of the FVIIa Bov level compared with 134 individuals homozygous for the FVII Arg353 allele. These decreases of FVIIa were greater than the decrease of FVIIc (17%), suggesting that FVII Gln353 may be difficult to activate in vivo. The marked decrease of FVIIa levels in individuals with the FVII Gln353 allele suggests that they are genetically protected against cardiovascular disease irrespective of ethnic background, by virtue of their decreased FVIIa level. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/7495068/Genetic_determinants_of_plasma_factor_VII_activity_in_the_Japanese_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:7495068 DB - PRIME DP - Unbound Medicine ER -