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Possible immunologic involvement of antioxidants in cancer prevention.
Am J Clin Nutr. 1995 12; 62(6 Suppl):1477S-1482S.AJ

Abstract

The people of Linxian County, China have one of the world's highest rates of esophageal cancer. Two intervention trials were conducted to determine whether supplementation with specific vitamins and minerals could lower mortality from or incidence of cancer in this population and whether supplementation with multiple vitamins and minerals would reduce esophageal and gastric cardia cancer in persons with esophageal dysplasia. About 30,000 general population (GP) subjects in the GP trial were randomly assigned to one of eight intervention groups according to a one-half replicate of a 2(4) factorial experimental design and were supplemented for 5.25 y with four combinations of micronutrients at doses from one to two times the US recommended dietary allowance (RDA). About 3000 subjects in whom dysplasia was diagnosed in the dysplasia trial were randomly assigned to groups receiving daily supplementation with 14 vitamins and 12 minerals at two to three times the US RDA or placebo for 6 y. Results of the dysplasia trial indicate that in individuals with esophageal dysplasia, micronutrient supplementation had little effect on T lymphocyte responses. In contrast, male participants in the GP trial who were supplemented with beta-carotene, vitamin E, and selenium showed significantly (P < 0.05) higher mitogenic responsiveness of T lymphocytes in vitro than those not receiving these micronutrients.

Authors+Show Affiliations

Cancer Institute, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7495248

Citation

Zhang, Y H., et al. "Possible Immunologic Involvement of Antioxidants in Cancer Prevention." The American Journal of Clinical Nutrition, vol. 62, no. 6 Suppl, 1995, 1477S-1482S.
Zhang YH, Kramer TR, Taylor PR, et al. Possible immunologic involvement of antioxidants in cancer prevention. Am J Clin Nutr. 1995;62(6 Suppl):1477S-1482S.
Zhang, Y. H., Kramer, T. R., Taylor, P. R., Li, J. Y., Blot, W. J., Brown, C. C., Guo, W., Dawsey, S. M., & Li, B. (1995). Possible immunologic involvement of antioxidants in cancer prevention. The American Journal of Clinical Nutrition, 62(6 Suppl), 1477S-1482S. https://doi.org/10.1093/ajcn/62.6.1477S
Zhang YH, et al. Possible Immunologic Involvement of Antioxidants in Cancer Prevention. Am J Clin Nutr. 1995;62(6 Suppl):1477S-1482S. PubMed PMID: 7495248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible immunologic involvement of antioxidants in cancer prevention. AU - Zhang,Y H, AU - Kramer,T R, AU - Taylor,P R, AU - Li,J Y, AU - Blot,W J, AU - Brown,C C, AU - Guo,W, AU - Dawsey,S M, AU - Li,B, PY - 1995/12/1/pubmed PY - 1995/12/1/medline PY - 1995/12/1/entrez SP - 1477S EP - 1482S JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 62 IS - 6 Suppl N2 - The people of Linxian County, China have one of the world's highest rates of esophageal cancer. Two intervention trials were conducted to determine whether supplementation with specific vitamins and minerals could lower mortality from or incidence of cancer in this population and whether supplementation with multiple vitamins and minerals would reduce esophageal and gastric cardia cancer in persons with esophageal dysplasia. About 30,000 general population (GP) subjects in the GP trial were randomly assigned to one of eight intervention groups according to a one-half replicate of a 2(4) factorial experimental design and were supplemented for 5.25 y with four combinations of micronutrients at doses from one to two times the US recommended dietary allowance (RDA). About 3000 subjects in whom dysplasia was diagnosed in the dysplasia trial were randomly assigned to groups receiving daily supplementation with 14 vitamins and 12 minerals at two to three times the US RDA or placebo for 6 y. Results of the dysplasia trial indicate that in individuals with esophageal dysplasia, micronutrient supplementation had little effect on T lymphocyte responses. In contrast, male participants in the GP trial who were supplemented with beta-carotene, vitamin E, and selenium showed significantly (P < 0.05) higher mitogenic responsiveness of T lymphocytes in vitro than those not receiving these micronutrients. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/7495248/Possible_immunologic_involvement_of_antioxidants_in_cancer_prevention_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/62.6.1477S DB - PRIME DP - Unbound Medicine ER -