Tags

Type your tag names separated by a space and hit enter

Effect of winter oral vitamin D3 supplementation on cardiovascular risk factors in elderly adults.
Eur J Clin Nutr 1995; 49(9):640-6EJ

Abstract

OBJECTIVE

A possible role for vitamin D deficiency in contributing to the winter increase in cardiovascular disease mortality was investigated by testing the effect of vitamin D supplementation on blood pressure and other cardiovascular risk factors during winter.

DESIGN

Randomised double-blind trial of vitamin D supplementation in winter.

SUBJECTS

Men and women, mean age 70 years (range 63-76) recruited from general practitioner age-sex registers in Cambridge (UK).

INTERVENTION

95 people received a single oral dose of 2.5 mg cholecalciferol and 94 received the placebo at baseline interviews during December 1991. Follow-up assessment was 5 weeks later during January 1992.

RESULTS

Comparing follow-up with baseline assessment, serum 25-hydroxyvitamin D increased in the treated group and decreased slightly in the placebo group [mean (s.d.) change: 7.2 (+/- 3.8) vs -1.4 (+/- 1.1) ng/ml, P = 0.0001]; while parathyroid hormone decreased in the treated, and increased in the placebo, group [-0.27 (+/- 0.78) vs 0.13 (+/- 0.75) pmol/l, P = 0.0004]. However, the mean change in blood pressure was similar in both groups: systolic -5 (+/- 13) vs -5 (+/- 16) mmHg, P = 0.81; diastolic -1 (+/- 9) vs -1 (+/- 9), P = 0.92; as was the mean change in serum cholesterol [-0.07 (+/- 0.52) vs -0.05 (+/- 0.60) mmol/l, P = 0.81]. In contrast, the mean change in radial pulse was significantly decreased in the treated group compared with placebo [-2 (+/- 9) vs 1 (+/- 7) beats per min, P = 0.030].

CONCLUSIONS

The failure of vitamin D supplementation to change blood pressure or serum cholesterol suggests that the winter increase in these factors is not caused by decreased vitamin D levels.

Authors+Show Affiliations

Clinical Gerontology Unit, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7498100

Citation

Scragg, R, et al. "Effect of Winter Oral Vitamin D3 Supplementation On Cardiovascular Risk Factors in Elderly Adults." European Journal of Clinical Nutrition, vol. 49, no. 9, 1995, pp. 640-6.
Scragg R, Khaw KT, Murphy S. Effect of winter oral vitamin D3 supplementation on cardiovascular risk factors in elderly adults. Eur J Clin Nutr. 1995;49(9):640-6.
Scragg, R., Khaw, K. T., & Murphy, S. (1995). Effect of winter oral vitamin D3 supplementation on cardiovascular risk factors in elderly adults. European Journal of Clinical Nutrition, 49(9), pp. 640-6.
Scragg R, Khaw KT, Murphy S. Effect of Winter Oral Vitamin D3 Supplementation On Cardiovascular Risk Factors in Elderly Adults. Eur J Clin Nutr. 1995;49(9):640-6. PubMed PMID: 7498100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of winter oral vitamin D3 supplementation on cardiovascular risk factors in elderly adults. AU - Scragg,R, AU - Khaw,K T, AU - Murphy,S, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 640 EP - 6 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 49 IS - 9 N2 - OBJECTIVE: A possible role for vitamin D deficiency in contributing to the winter increase in cardiovascular disease mortality was investigated by testing the effect of vitamin D supplementation on blood pressure and other cardiovascular risk factors during winter. DESIGN: Randomised double-blind trial of vitamin D supplementation in winter. SUBJECTS: Men and women, mean age 70 years (range 63-76) recruited from general practitioner age-sex registers in Cambridge (UK). INTERVENTION: 95 people received a single oral dose of 2.5 mg cholecalciferol and 94 received the placebo at baseline interviews during December 1991. Follow-up assessment was 5 weeks later during January 1992. RESULTS: Comparing follow-up with baseline assessment, serum 25-hydroxyvitamin D increased in the treated group and decreased slightly in the placebo group [mean (s.d.) change: 7.2 (+/- 3.8) vs -1.4 (+/- 1.1) ng/ml, P = 0.0001]; while parathyroid hormone decreased in the treated, and increased in the placebo, group [-0.27 (+/- 0.78) vs 0.13 (+/- 0.75) pmol/l, P = 0.0004]. However, the mean change in blood pressure was similar in both groups: systolic -5 (+/- 13) vs -5 (+/- 16) mmHg, P = 0.81; diastolic -1 (+/- 9) vs -1 (+/- 9), P = 0.92; as was the mean change in serum cholesterol [-0.07 (+/- 0.52) vs -0.05 (+/- 0.60) mmol/l, P = 0.81]. In contrast, the mean change in radial pulse was significantly decreased in the treated group compared with placebo [-2 (+/- 9) vs 1 (+/- 7) beats per min, P = 0.030]. CONCLUSIONS: The failure of vitamin D supplementation to change blood pressure or serum cholesterol suggests that the winter increase in these factors is not caused by decreased vitamin D levels. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/7498100/Effect_of_winter_oral_vitamin_D3_supplementation_on_cardiovascular_risk_factors_in_elderly_adults_ L2 - https://medlineplus.gov/vitaminddeficiency.html DB - PRIME DP - Unbound Medicine ER -