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USP dissolution apparatus 3 (reciprocating cylinder): instrument parameter effects on drug release from sustained release formulations.
J Pharm Sci. 1995 Aug; 84(8):922-6.JP

Abstract

The United States Pharmacopoeia dissolution apparatus 3 (reciprocating cylinder) was evaluated with respect to effects of changes in instrument parameters on drug release rate from six hydrophilic matrix formulations and one coated-bead formulation. Reciprocation rate had the largest effect on time to 50% release for all matrix formulations. Top mesh size had an effect on release rate for those formulations having an erosion component to the drug release mechanism. Bottom mesh size had no effect on release rate. For the coated-bead formulation, no parameter had an effect on release rate. In an assessment of the hydrodynamics of the reciprocating cylinders, conditions equivalent to the 50 rpm paddle and 100 rpm basket were determined to be at the extreme low end of the available reciprocation rate range.

Links

Publisher Full Text
linkinghub.elsevier.com
onlinelibrary.wiley.com

Authors+Show Affiliations

Rohrs BR
Analytical Research and Specifications Development, Upjohn Company, Kalamazoo, MI, USA.
Burch-Clark DL
No affiliation info available
Witt MJ
No affiliation info available
Stelzer DJ
No affiliation info available

MeSH

Chemistry, PharmaceuticalDelayed-Action PreparationsDiffusionIbuprofenPharmacopoeias as TopicSolubilityUnited States

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7500274

Citation

Rohrs, B R., et al. "USP Dissolution Apparatus 3 (reciprocating Cylinder): Instrument Parameter Effects On Drug Release From Sustained Release Formulations." Journal of Pharmaceutical Sciences, vol. 84, no. 8, 1995, pp. 922-6.
Rohrs BR, Burch-Clark DL, Witt MJ, et al. USP dissolution apparatus 3 (reciprocating cylinder): instrument parameter effects on drug release from sustained release formulations. J Pharm Sci. 1995;84(8):922-6.
Rohrs, B. R., Burch-Clark, D. L., Witt, M. J., & Stelzer, D. J. (1995). USP dissolution apparatus 3 (reciprocating cylinder): instrument parameter effects on drug release from sustained release formulations. Journal of Pharmaceutical Sciences, 84(8), 922-6.
Rohrs BR, et al. USP Dissolution Apparatus 3 (reciprocating Cylinder): Instrument Parameter Effects On Drug Release From Sustained Release Formulations. J Pharm Sci. 1995;84(8):922-6. PubMed PMID: 7500274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - USP dissolution apparatus 3 (reciprocating cylinder): instrument parameter effects on drug release from sustained release formulations. AU - Rohrs,B R, AU - Burch-Clark,D L, AU - Witt,M J, AU - Stelzer,D J, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 922 EP - 6 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 84 IS - 8 N2 - The United States Pharmacopoeia dissolution apparatus 3 (reciprocating cylinder) was evaluated with respect to effects of changes in instrument parameters on drug release rate from six hydrophilic matrix formulations and one coated-bead formulation. Reciprocation rate had the largest effect on time to 50% release for all matrix formulations. Top mesh size had an effect on release rate for those formulations having an erosion component to the drug release mechanism. Bottom mesh size had no effect on release rate. For the coated-bead formulation, no parameter had an effect on release rate. In an assessment of the hydrodynamics of the reciprocating cylinders, conditions equivalent to the 50 rpm paddle and 100 rpm basket were determined to be at the extreme low end of the available reciprocation rate range. SN - 0022-3549 UR - https://www.unboundmedicine.com/medline/citation/7500274/USP_dissolution_apparatus_3__reciprocating_cylinder_:_instrument_parameter_effects_on_drug_release_from_sustained_release_formulations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3549(15)49860-0 DB - PRIME DP - Unbound Medicine ER -