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Rapid GC-MS confirmation of urinary amphetamine and methamphetamine as their propylchloroformate derivatives.
J Anal Toxicol. 1995 Sep; 19(5):316-22.JA

Abstract

Amphetamine and methamphetamine are extracted from 200 microL of urine into an organic solvent containing propylchloroformate. The amines immediately react to form propylcarbamate derivatives. The aqueous phase is removed, and a portion of the organic phase is analyzed by gas chromatography-mass spectrometry. Either the deuterated analogues or N-propylamphetamine internal standards give acceptable results. For day-to-day precision, coefficients of variation in the range of 6-10% are found. The method is linear to 10,000 ng/mL. Limits of quantitation and detection are 50 and 5 ng/mL, respectively, when using N-propylamphetamine as the internal standard. Extracts are stable at room temperature for at least 60 days. There is no interference from other amphetamine drugs.

Authors+Show Affiliations

Department of Biochemistry, St. Boniface General Hospital, Winnipeg, MB, Canada.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7500619

Citation

Meatherall, R. "Rapid GC-MS Confirmation of Urinary Amphetamine and Methamphetamine as Their Propylchloroformate Derivatives." Journal of Analytical Toxicology, vol. 19, no. 5, 1995, pp. 316-22.
Meatherall R. Rapid GC-MS confirmation of urinary amphetamine and methamphetamine as their propylchloroformate derivatives. J Anal Toxicol. 1995;19(5):316-22.
Meatherall, R. (1995). Rapid GC-MS confirmation of urinary amphetamine and methamphetamine as their propylchloroformate derivatives. Journal of Analytical Toxicology, 19(5), 316-22.
Meatherall R. Rapid GC-MS Confirmation of Urinary Amphetamine and Methamphetamine as Their Propylchloroformate Derivatives. J Anal Toxicol. 1995;19(5):316-22. PubMed PMID: 7500619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid GC-MS confirmation of urinary amphetamine and methamphetamine as their propylchloroformate derivatives. A1 - Meatherall,R, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 316 EP - 22 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 19 IS - 5 N2 - Amphetamine and methamphetamine are extracted from 200 microL of urine into an organic solvent containing propylchloroformate. The amines immediately react to form propylcarbamate derivatives. The aqueous phase is removed, and a portion of the organic phase is analyzed by gas chromatography-mass spectrometry. Either the deuterated analogues or N-propylamphetamine internal standards give acceptable results. For day-to-day precision, coefficients of variation in the range of 6-10% are found. The method is linear to 10,000 ng/mL. Limits of quantitation and detection are 50 and 5 ng/mL, respectively, when using N-propylamphetamine as the internal standard. Extracts are stable at room temperature for at least 60 days. There is no interference from other amphetamine drugs. SN - 0146-4760 UR - https://www.unboundmedicine.com/medline/citation/7500619/Rapid_GC_MS_confirmation_of_urinary_amphetamine_and_methamphetamine_as_their_propylchloroformate_derivatives_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/19.5.316 DB - PRIME DP - Unbound Medicine ER -