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[Long-term prognosis of chronic B and C viral hepatitis].
Leber Magen Darm 1995; 25(5):205-10LM

Abstract

146 patients (62 female, 84 male) with chronic hepatitis B and 80 patients (34 female, 46 male) with chronic hepatitis C were regularly examined in 1 to 2 year intervals with an average follow-up period of 12 years (mean). Each time patients were evaluated by physical examination, routine laboratory data, immunological and serological testing, ultrasonography, and laparoscopy and/or percutaneous liver biopsy. No patient of the study underwent immunosuppressive or antiviral treatment at any time.-The average time data in years are given as the median value (mean). Chronic hepatitis B: Histologic diagnoses and their long-term prognosis: Chronic persistent hepatitis (CPH) on first biopsy: 10% of cases complete recovery after 15 years, 70% progression to chronic active hepatitis (CAH) after 5 years; CAH: 30% advanced remission/complete recovery 8 years after the first diagnosis of CAH, 40% progression to liver cirrhosis after 5 years; liver cirrhosis: 50% advanced remission/recovery 4 years after the first diagnosis of cirrhosis, 5% developed a hepatocellular carcinoma (HCC) 11 years after the first diagnosis of cirrhosis. Natural history: In the 11 years following initial diagnosis of HBV-infection spontaneous recovery was observed in 49% of cases. In 3% of the patients the disease eventually caused death (1 x hemorrhage of oesophageal varices, 3x HCC after 14 to 20 years). Chronic hepatitis C: All patients were anti-HCV- and HCV-RNA-positive.-There was no spontaneous elimination of virus in any patient (maximal follow-up 27 years).(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Klinik Wartenberg, Wartenberg, Obb.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

7500807

Citation

Ohlen, J, et al. "[Long-term Prognosis of Chronic B and C Viral Hepatitis]." Leber, Magen, Darm, vol. 25, no. 5, 1995, pp. 205-10.
Ohlen J, Liegl JM, Selmair H. [Long-term prognosis of chronic B and C viral hepatitis]. Leber Magen Darm. 1995;25(5):205-10.
Ohlen, J., Liegl, J. M., & Selmair, H. (1995). [Long-term prognosis of chronic B and C viral hepatitis]. Leber, Magen, Darm, 25(5), pp. 205-10.
Ohlen J, Liegl JM, Selmair H. [Long-term Prognosis of Chronic B and C Viral Hepatitis]. Leber Magen Darm. 1995;25(5):205-10. PubMed PMID: 7500807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Long-term prognosis of chronic B and C viral hepatitis]. AU - Ohlen,J, AU - Liegl,J M, AU - Selmair,H, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 205 EP - 10 JF - Leber, Magen, Darm JO - Leber Magen Darm VL - 25 IS - 5 N2 - 146 patients (62 female, 84 male) with chronic hepatitis B and 80 patients (34 female, 46 male) with chronic hepatitis C were regularly examined in 1 to 2 year intervals with an average follow-up period of 12 years (mean). Each time patients were evaluated by physical examination, routine laboratory data, immunological and serological testing, ultrasonography, and laparoscopy and/or percutaneous liver biopsy. No patient of the study underwent immunosuppressive or antiviral treatment at any time.-The average time data in years are given as the median value (mean). Chronic hepatitis B: Histologic diagnoses and their long-term prognosis: Chronic persistent hepatitis (CPH) on first biopsy: 10% of cases complete recovery after 15 years, 70% progression to chronic active hepatitis (CAH) after 5 years; CAH: 30% advanced remission/complete recovery 8 years after the first diagnosis of CAH, 40% progression to liver cirrhosis after 5 years; liver cirrhosis: 50% advanced remission/recovery 4 years after the first diagnosis of cirrhosis, 5% developed a hepatocellular carcinoma (HCC) 11 years after the first diagnosis of cirrhosis. Natural history: In the 11 years following initial diagnosis of HBV-infection spontaneous recovery was observed in 49% of cases. In 3% of the patients the disease eventually caused death (1 x hemorrhage of oesophageal varices, 3x HCC after 14 to 20 years). Chronic hepatitis C: All patients were anti-HCV- and HCV-RNA-positive.-There was no spontaneous elimination of virus in any patient (maximal follow-up 27 years).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0300-8622 UR - https://www.unboundmedicine.com/medline/citation/7500807/[Long_term_prognosis_of_chronic_B_and_C_viral_hepatitis]_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -