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SAPHO syndrome.
Radiographics 1995; 15(5):1147-54R

Abstract

Palmoplantar pustulosis and severe acne are sometimes associated with peculiar aseptic skeletal conditions, but such skeletal lesions can be found without skin lesions. The term SAPHO syndrome has been coined for this cluster of manifestations. (The acronym SAPHO refers to synovitis, acne, palmoplantar pustulosis, hyperostosis, and osteitis.) The most common site of the disease is the upper anterior chest wall, characterized by predominantly osteosclerotic lesions, hyperostosis, and arthritis of the adjacent joints. Osteosclerosis of the vertebral bodies, hyperostosis, and erosions of the vertebral plates can be encountered. Unilateral sacroiliitis is frequently observed. Long bone involvement consists of osteosclerosis or osteolysis with periosteal new bone formation. Peripheral arthritis can be present but is rarely associated with joint destruction. The pathogenesis of this syndrome remains unknown, but a link with seronegative spondyloarthropathies is probable. Radiologists should be aware of this unusual syndrome to avoid misdiagnosis (eg, tumor, infection), unnecessary surgery, and antibiotic therapy.

Authors+Show Affiliations

Department of Radiology, Hospital B, Centre Hospitalier Regional Universitaire de Lille, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7501856

Citation

Cotten, A, et al. "SAPHO Syndrome." Radiographics : a Review Publication of the Radiological Society of North America, Inc, vol. 15, no. 5, 1995, pp. 1147-54.
Cotten A, Flipo RM, Mentre A, et al. SAPHO syndrome. Radiographics. 1995;15(5):1147-54.
Cotten, A., Flipo, R. M., Mentre, A., Delaporte, E., Duquesnoy, B., & Chastanet, P. (1995). SAPHO syndrome. Radiographics : a Review Publication of the Radiological Society of North America, Inc, 15(5), pp. 1147-54.
Cotten A, et al. SAPHO Syndrome. Radiographics. 1995;15(5):1147-54. PubMed PMID: 7501856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SAPHO syndrome. AU - Cotten,A, AU - Flipo,R M, AU - Mentre,A, AU - Delaporte,E, AU - Duquesnoy,B, AU - Chastanet,P, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 1147 EP - 54 JF - Radiographics : a review publication of the Radiological Society of North America, Inc JO - Radiographics VL - 15 IS - 5 N2 - Palmoplantar pustulosis and severe acne are sometimes associated with peculiar aseptic skeletal conditions, but such skeletal lesions can be found without skin lesions. The term SAPHO syndrome has been coined for this cluster of manifestations. (The acronym SAPHO refers to synovitis, acne, palmoplantar pustulosis, hyperostosis, and osteitis.) The most common site of the disease is the upper anterior chest wall, characterized by predominantly osteosclerotic lesions, hyperostosis, and arthritis of the adjacent joints. Osteosclerosis of the vertebral bodies, hyperostosis, and erosions of the vertebral plates can be encountered. Unilateral sacroiliitis is frequently observed. Long bone involvement consists of osteosclerosis or osteolysis with periosteal new bone formation. Peripheral arthritis can be present but is rarely associated with joint destruction. The pathogenesis of this syndrome remains unknown, but a link with seronegative spondyloarthropathies is probable. Radiologists should be aware of this unusual syndrome to avoid misdiagnosis (eg, tumor, infection), unnecessary surgery, and antibiotic therapy. SN - 0271-5333 UR - https://www.unboundmedicine.com/medline/citation/7501856/SAPHO_syndrome_ L2 - http://pubs.rsna.org/doi/10.1148/radiographics.15.5.7501856?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -