Tags

Type your tag names separated by a space and hit enter

Serum ferritin in beta-thalassemia trait.
Isr J Med Sci 1978; 14(11):1127-31IJ

Abstract

The diagnostic value of serum ferritin measurements in discriminating iron-deficiency anemia from thalassemia trait has been studied. In contrast to serum iron, percent transferrin saturation and total iron-binding capacity, where a high degree of overlap existed between the two groups, a clear-cut difference in serum ferritin levels was found between iron deficiency and thalassemia trait. The best separation of iron deficiency, thalassemia and normal controls was given by the combination of mean corpuscular volume and serum ferritin. Although definitive diagnosis of beta-thalassemia trait requires the demonstration of abnormal Hb A2 levels or beta-chain synthesis, serum ferritin is a useful screening test for the initial diagnosis of thalassemia trait. Because of the very small amounts of serum required for the measurement of ferritin, it is particularly suitable for surveying populations with a high prevalence of hypochromic-microcytic anemias.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

750537

Citation

Loria, A, et al. "Serum Ferritin in Beta-thalassemia Trait." Israel Journal of Medical Sciences, vol. 14, no. 11, 1978, pp. 1127-31.
Loria A, Konijn AM, Hershko C. Serum ferritin in beta-thalassemia trait. Isr J Med Sci. 1978;14(11):1127-31.
Loria, A., Konijn, A. M., & Hershko, C. (1978). Serum ferritin in beta-thalassemia trait. Israel Journal of Medical Sciences, 14(11), pp. 1127-31.
Loria A, Konijn AM, Hershko C. Serum Ferritin in Beta-thalassemia Trait. Isr J Med Sci. 1978;14(11):1127-31. PubMed PMID: 750537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum ferritin in beta-thalassemia trait. AU - Loria,A, AU - Konijn,A M, AU - Hershko,C, PY - 1978/11/1/pubmed PY - 1978/11/1/medline PY - 1978/11/1/entrez SP - 1127 EP - 31 JF - Israel journal of medical sciences JO - Isr. J. Med. Sci. VL - 14 IS - 11 N2 - The diagnostic value of serum ferritin measurements in discriminating iron-deficiency anemia from thalassemia trait has been studied. In contrast to serum iron, percent transferrin saturation and total iron-binding capacity, where a high degree of overlap existed between the two groups, a clear-cut difference in serum ferritin levels was found between iron deficiency and thalassemia trait. The best separation of iron deficiency, thalassemia and normal controls was given by the combination of mean corpuscular volume and serum ferritin. Although definitive diagnosis of beta-thalassemia trait requires the demonstration of abnormal Hb A2 levels or beta-chain synthesis, serum ferritin is a useful screening test for the initial diagnosis of thalassemia trait. Because of the very small amounts of serum required for the measurement of ferritin, it is particularly suitable for surveying populations with a high prevalence of hypochromic-microcytic anemias. SN - 0021-2180 UR - https://www.unboundmedicine.com/medline/citation/750537/Serum_ferritin_in_beta_thalassemia_trait_ L2 - http://www.diseaseinfosearch.org/result/814 DB - PRIME DP - Unbound Medicine ER -