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Acute myeloid leukemia possibly producing thrombopoietic factor(s).
Jpn J Clin Oncol. 1993 Dec; 23(6):366-72.JJ

Abstract

A 75-year-old man developed a cluster of differentiation (CD)4-positive but human T-cell lymphotropic virus type I (HTLV-I)-negative T lymphoid neoplasm with overwhelming cutaneous involvement and mild thrombocytosis. Twelve courses tetrahydropyranyl adriamycin, cyclophosphamide, vincristine and prednisone (THP-COP) combination chemotherapy led him to complete remission. After four months of complete remission, however, atypical immature cells (blasts) appeared in peripheral blood and bone marrow. Surface marker analysis revealed the blasts to be CD2-, CD3-, CD4-, CD5-, CD7+, CD8-, CD10, CD13 +/-, CD19-, CD20-, CD25-, CD33+ and human leukocyte antigen-DR (HLA-DR+). Staining for myeloperoxidase, esterases, PAS and platelet peroxidase were all negative. The patient was diagnosed as having both CD7 and CD33 positive acute myeloid leukemia (AML). The relation between the T cell lymphoid neoplasm and AML was not clear. Thrombocytosis became more marked after acute leukemia occurred and the platelet count varied in parallel with the blast cell count in peripheral blood. When the leukemic cell count was high, thrombopoietic activity could be detected in the serum. In addition, conditioned medium obtained from primarily-cultured blasts had detectable thrombopoietic activity, which implied the blasts directly to produce a thrombopoietic factor(s). Analysis of the serum concentration for cytokines with associated thrombopoietic activity indicated that the blasts possibly produced a thrombopoietic factor(s) distinct from interleukin (IL)6, IL3, leukemia inhibitory factor (LIF), erythropoietin and granulocyte macrophage-colony stimulating factor. To our knowledge, this is the first reported case of an acute myeloid leukemia with marked thrombopoiesis (more than 2000 x 10(3)/microliter of maximum platelet count in peripheral blood.

Authors+Show Affiliations

Fourth Department of Internal Medicine, Faculty of Medicine, University of Tokyo.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

7506802

Citation

Fujita, A, et al. "Acute Myeloid Leukemia Possibly Producing Thrombopoietic Factor(s)." Japanese Journal of Clinical Oncology, vol. 23, no. 6, 1993, pp. 366-72.
Fujita A, Matsuoka M, Shimonaka Y, et al. Acute myeloid leukemia possibly producing thrombopoietic factor(s). Jpn J Clin Oncol. 1993;23(6):366-72.
Fujita, A., Matsuoka, M., Shimonaka, Y., Imai, N., & Asano, S. (1993). Acute myeloid leukemia possibly producing thrombopoietic factor(s). Japanese Journal of Clinical Oncology, 23(6), 366-72.
Fujita A, et al. Acute Myeloid Leukemia Possibly Producing Thrombopoietic Factor(s). Jpn J Clin Oncol. 1993;23(6):366-72. PubMed PMID: 7506802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute myeloid leukemia possibly producing thrombopoietic factor(s). AU - Fujita,A, AU - Matsuoka,M, AU - Shimonaka,Y, AU - Imai,N, AU - Asano,S, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 366 EP - 72 JF - Japanese journal of clinical oncology JO - Jpn J Clin Oncol VL - 23 IS - 6 N2 - A 75-year-old man developed a cluster of differentiation (CD)4-positive but human T-cell lymphotropic virus type I (HTLV-I)-negative T lymphoid neoplasm with overwhelming cutaneous involvement and mild thrombocytosis. Twelve courses tetrahydropyranyl adriamycin, cyclophosphamide, vincristine and prednisone (THP-COP) combination chemotherapy led him to complete remission. After four months of complete remission, however, atypical immature cells (blasts) appeared in peripheral blood and bone marrow. Surface marker analysis revealed the blasts to be CD2-, CD3-, CD4-, CD5-, CD7+, CD8-, CD10, CD13 +/-, CD19-, CD20-, CD25-, CD33+ and human leukocyte antigen-DR (HLA-DR+). Staining for myeloperoxidase, esterases, PAS and platelet peroxidase were all negative. The patient was diagnosed as having both CD7 and CD33 positive acute myeloid leukemia (AML). The relation between the T cell lymphoid neoplasm and AML was not clear. Thrombocytosis became more marked after acute leukemia occurred and the platelet count varied in parallel with the blast cell count in peripheral blood. When the leukemic cell count was high, thrombopoietic activity could be detected in the serum. In addition, conditioned medium obtained from primarily-cultured blasts had detectable thrombopoietic activity, which implied the blasts directly to produce a thrombopoietic factor(s). Analysis of the serum concentration for cytokines with associated thrombopoietic activity indicated that the blasts possibly produced a thrombopoietic factor(s) distinct from interleukin (IL)6, IL3, leukemia inhibitory factor (LIF), erythropoietin and granulocyte macrophage-colony stimulating factor. To our knowledge, this is the first reported case of an acute myeloid leukemia with marked thrombopoiesis (more than 2000 x 10(3)/microliter of maximum platelet count in peripheral blood. SN - 0368-2811 UR - https://www.unboundmedicine.com/medline/citation/7506802/Acute_myeloid_leukemia_possibly_producing_thrombopoietic_factor_s__ L2 - http://www.diseaseinfosearch.org/result/4195 DB - PRIME DP - Unbound Medicine ER -