Tags

Type your tag names separated by a space and hit enter

Platelet substance P and 5-hydroxytryptamine in migraine and tension-type headache.
Headache. 1993 Nov-Dec; 33(10):528-32.H

Abstract

Levels of substance P (SP) and 5-hydroxytryptamine (5-HT) in platelets were measured in 25 patients with migraine, 31 patients with tension-type headache (TH) and 27 healthy controls. The mean concentration of SP in platelets was 355.3 pg/10(9) platelets in patients with migraine, 290.8 pg/10(9) platelets in patients with TH and 180.8 pg/10(9) platelets in the controls. The concentrations of platelet SP in the migrainous patients and in the TH patients were significantly higher than those in the controls. The mean concentration of 5-HT in platelets was 619.7 ng/10(9) platelets in patients with migraine, 579.3 ng/10(9) platelets in patients with TH and 811.9 ng/10(9) platelets in the controls. The concentration of platelet 5-HT in the patients with TH was significantly lower than that in the controls. The platelet SP/5-HT ratio in the migrainous patients and in the TH patients were significantly higher than that in the controls. There was significant negative correlation between the concentrations of platelet SP and those of platelet 5-HT. These results may support the hypothesis that SP released from the terminals of the trigeminal nerves causes migraine either through direct actions on the vessels or by releasing 5-HT from the platelets. The high levels of platelet SP in TH patients might reflect release of SP from the pain sensory system.

Authors+Show Affiliations

Division of Neurology, Faculty of Medicine, Tottori University, Yonago, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7507472

Citation

Nakano, T, et al. "Platelet Substance P and 5-hydroxytryptamine in Migraine and Tension-type Headache." Headache, vol. 33, no. 10, 1993, pp. 528-32.
Nakano T, Shimomura T, Takahashi K, et al. Platelet substance P and 5-hydroxytryptamine in migraine and tension-type headache. Headache. 1993;33(10):528-32.
Nakano, T., Shimomura, T., Takahashi, K., & Ikawa, S. (1993). Platelet substance P and 5-hydroxytryptamine in migraine and tension-type headache. Headache, 33(10), 528-32.
Nakano T, et al. Platelet Substance P and 5-hydroxytryptamine in Migraine and Tension-type Headache. Headache. 1993 Nov-Dec;33(10):528-32. PubMed PMID: 7507472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Platelet substance P and 5-hydroxytryptamine in migraine and tension-type headache. AU - Nakano,T, AU - Shimomura,T, AU - Takahashi,K, AU - Ikawa,S, PY - 1993/11/1/pubmed PY - 1993/11/1/medline PY - 1993/11/1/entrez SP - 528 EP - 32 JF - Headache JO - Headache VL - 33 IS - 10 N2 - Levels of substance P (SP) and 5-hydroxytryptamine (5-HT) in platelets were measured in 25 patients with migraine, 31 patients with tension-type headache (TH) and 27 healthy controls. The mean concentration of SP in platelets was 355.3 pg/10(9) platelets in patients with migraine, 290.8 pg/10(9) platelets in patients with TH and 180.8 pg/10(9) platelets in the controls. The concentrations of platelet SP in the migrainous patients and in the TH patients were significantly higher than those in the controls. The mean concentration of 5-HT in platelets was 619.7 ng/10(9) platelets in patients with migraine, 579.3 ng/10(9) platelets in patients with TH and 811.9 ng/10(9) platelets in the controls. The concentration of platelet 5-HT in the patients with TH was significantly lower than that in the controls. The platelet SP/5-HT ratio in the migrainous patients and in the TH patients were significantly higher than that in the controls. There was significant negative correlation between the concentrations of platelet SP and those of platelet 5-HT. These results may support the hypothesis that SP released from the terminals of the trigeminal nerves causes migraine either through direct actions on the vessels or by releasing 5-HT from the platelets. The high levels of platelet SP in TH patients might reflect release of SP from the pain sensory system. SN - 0017-8748 UR - https://www.unboundmedicine.com/medline/citation/7507472/Platelet_substance_P_and_5_hydroxytryptamine_in_migraine_and_tension_type_headache_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0017-8748&date=1993&volume=33&issue=10&spage=528 DB - PRIME DP - Unbound Medicine ER -