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Two potentially angiostatic factors, a steroid and L-azetidine-2-carboxylic acid, antagonize one another.
Int J Microcirc Clin Exp. 1993 Oct; 13(2):113-24.IJ

Abstract

The proline analogue L-azetidine-2-carboxylic acid (LACA) systemically suppressed mast-cell-mediated angiogenesis, as measured by the rat mesenteric-window method. Dexamethasone and methylprednisolone at very low and non-toxic s.c. doses also somewhat inhibited the angiogenesis. Most interestingly, the co-administration of either of these steroids with LACA paradoxically stimulated angiogenesis. These findings suggest that in the future search for candidates for clinically-useful systemic angiostatic remedies, one may have to focus not only on the effect of individual drugs or agents, but also on the effect of such putative anti-angiogenic agents when co-administered. The fact that two potentially angiostatic agents can antagonize one another has not previously been reported.

Authors+Show Affiliations

Norrby K
Department of Pathology, Sahlgren Hospital, Göteborg, Sweden.
Jakobsson A
No affiliation info available
Nilsson CL
No affiliation info available

MeSH

AnimalsAzetidinecarboxylic AcidDexamethasoneDrug Therapy, CombinationMaleMast CellsMethylprednisoloneNeovascularization, PathologicRatsRats, Sprague-DawleyWeight Gain

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7508426

Citation

Norrby, K, et al. "Two Potentially Angiostatic Factors, a Steroid and L-azetidine-2-carboxylic Acid, Antagonize One Another." International Journal of Microcirculation, Clinical and Experimental, vol. 13, no. 2, 1993, pp. 113-24.
Norrby K, Jakobsson A, Nilsson CL. Two potentially angiostatic factors, a steroid and L-azetidine-2-carboxylic acid, antagonize one another. Int J Microcirc Clin Exp. 1993;13(2):113-24.
Norrby, K., Jakobsson, A., & Nilsson, C. L. (1993). Two potentially angiostatic factors, a steroid and L-azetidine-2-carboxylic acid, antagonize one another. International Journal of Microcirculation, Clinical and Experimental, 13(2), 113-24.
Norrby K, Jakobsson A, Nilsson CL. Two Potentially Angiostatic Factors, a Steroid and L-azetidine-2-carboxylic Acid, Antagonize One Another. Int J Microcirc Clin Exp. 1993;13(2):113-24. PubMed PMID: 7508426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two potentially angiostatic factors, a steroid and L-azetidine-2-carboxylic acid, antagonize one another. AU - Norrby,K, AU - Jakobsson,A, AU - Nilsson,C L, PY - 1993/10/1/pubmed PY - 1993/10/1/medline PY - 1993/10/1/entrez SP - 113 EP - 24 JF - International journal of microcirculation, clinical and experimental JO - Int J Microcirc Clin Exp VL - 13 IS - 2 N2 - The proline analogue L-azetidine-2-carboxylic acid (LACA) systemically suppressed mast-cell-mediated angiogenesis, as measured by the rat mesenteric-window method. Dexamethasone and methylprednisolone at very low and non-toxic s.c. doses also somewhat inhibited the angiogenesis. Most interestingly, the co-administration of either of these steroids with LACA paradoxically stimulated angiogenesis. These findings suggest that in the future search for candidates for clinically-useful systemic angiostatic remedies, one may have to focus not only on the effect of individual drugs or agents, but also on the effect of such putative anti-angiogenic agents when co-administered. The fact that two potentially angiostatic agents can antagonize one another has not previously been reported. SN - 0167-6865 UR - https://www.unboundmedicine.com/medline/citation/7508426/Two_potentially_angiostatic_factors_a_steroid_and_L_azetidine_2_carboxylic_acid_antagonize_one_another_ DB - PRIME DP - Unbound Medicine ER -