Tags

Type your tag names separated by a space and hit enter

Structure and expression of Spk-1, an src-related gene product found in the planarian Dugesia (G) tigrina.
Oncogene 1994; 9(4):1267-72O

Abstract

A cDNA clone encoding a 497 amino acid protein 75% similar to most Src proteins has been isolated from the planarian Dugesia (Girardia) tigrina (Platyhelminthes; Turbellaria) by PCR followed by screening procedures. This gene product has been designated Spk-1 as it is the first Src-related kinase isolated in a planarian. The predicted amino acid sequence of Spk-1 suggest that it is anchored to the plasma membrane and that it interacts with other phosphotyrosine proteins. Spk-1 is expressed in both intact and regenerating organisms as an mRNA transcript of about 1.9 kb. Planarians, which conserve most features of the common ancestor to protostomian and deuterostomian phyla, are the most primitive triploblastic organisms from which a protein tyrosine kinase gene product has been isolated. The presence of this gene product in such a primitive organism, and its presumed role, are discussed.

Authors+Show Affiliations

Department de Genètica, Facultat de Biologia, Universitat de Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7510865

Citation

Burgaya, F, et al. "Structure and Expression of Spk-1, an Src-related Gene Product Found in the Planarian Dugesia (G) Tigrina." Oncogene, vol. 9, no. 4, 1994, pp. 1267-72.
Burgaya F, Garcia-Fernàndez J, Riutort M, et al. Structure and expression of Spk-1, an src-related gene product found in the planarian Dugesia (G) tigrina. Oncogene. 1994;9(4):1267-72.
Burgaya, F., Garcia-Fernàndez, J., Riutort, M., Baguñà, J., & Saló, E. (1994). Structure and expression of Spk-1, an src-related gene product found in the planarian Dugesia (G) tigrina. Oncogene, 9(4), pp. 1267-72.
Burgaya F, et al. Structure and Expression of Spk-1, an Src-related Gene Product Found in the Planarian Dugesia (G) Tigrina. Oncogene. 1994;9(4):1267-72. PubMed PMID: 7510865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structure and expression of Spk-1, an src-related gene product found in the planarian Dugesia (G) tigrina. AU - Burgaya,F, AU - Garcia-Fernàndez,J, AU - Riutort,M, AU - Baguñà,J, AU - Saló,E, PY - 1994/4/1/pubmed PY - 1994/4/1/medline PY - 1994/4/1/entrez SP - 1267 EP - 72 JF - Oncogene JO - Oncogene VL - 9 IS - 4 N2 - A cDNA clone encoding a 497 amino acid protein 75% similar to most Src proteins has been isolated from the planarian Dugesia (Girardia) tigrina (Platyhelminthes; Turbellaria) by PCR followed by screening procedures. This gene product has been designated Spk-1 as it is the first Src-related kinase isolated in a planarian. The predicted amino acid sequence of Spk-1 suggest that it is anchored to the plasma membrane and that it interacts with other phosphotyrosine proteins. Spk-1 is expressed in both intact and regenerating organisms as an mRNA transcript of about 1.9 kb. Planarians, which conserve most features of the common ancestor to protostomian and deuterostomian phyla, are the most primitive triploblastic organisms from which a protein tyrosine kinase gene product has been isolated. The presence of this gene product in such a primitive organism, and its presumed role, are discussed. SN - 0950-9232 UR - https://www.unboundmedicine.com/medline/citation/7510865/Structure_and_expression_of_Spk_1_an_src_related_gene_product_found_in_the_planarian_Dugesia<strong>G</strong>tigrina_ DB - PRIME DP - Unbound Medicine ER -