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Three-year outcome of children exposed prenatally to drugs.
J Am Acad Child Adolesc Psychiatry. 1994 Jan; 33(1):20-7.JA

Abstract

OBJECTIVE

To evaluate the 3-year behavioral and developmental outcome of children prenatally exposed to maternal substances of abuse.

METHOD

Ninety-three children exposed prenatally to cocaine and other drugs taken by the mother during pregnancy (Group 1), 24 polydrug/noncocaine exposed children (Group 2), and 25 nonexposed children (Group 3) were evaluated at 3 years of age as part of a longitudinal prospective study of the impact of intrauterine substance exposure on long-term outcome. The Stanford-Binet Intelligence Scale: Fourth Edition(SBIS) was administered by examiners blinded to the exposure background of the children, and a pediatrician performed a complete medical evaluation on all the children. The children's primary caregiver completed the Achenbach Child Behavior Checklist. Stepwise multiple regression procedures were used to determine the factors that best predicted 3-year growth, intelligence, and behavior.

RESULTS

Groups 1 and 2 differed from Group 3 on head circumference. Group 1 scored lower than Group 3 on SBIS Verbal Reasoning. Group 2 scored Slower than Group 3 on SBIS Abstract/Visual Reasoning. Cocaine exposure predicted poor verbal reasoning. Marijuana exposure predicted poor abstract/visual reasoning. Examiner rating predicted intellectual outcome and caregiver ratings. Caregivers rated exposed children as more aggressive than nonexposed.

CONCLUSION

Contrary to information in the popular media, not all substance-exposed children suffer the same poor prognosis. In fact, generalizations about the fate of drug-exposed children must await additional research into the outcome of the broader population of drug-exposed children, examining the roles of maternal and environmental factors across a variety of geographic locations and socioeconomic levels.

Authors+Show Affiliations

National Association for Perinatal Addiction Research and Education, Chicago, IL 60611.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7511139

Citation

Griffith, D R., et al. "Three-year Outcome of Children Exposed Prenatally to Drugs." Journal of the American Academy of Child and Adolescent Psychiatry, vol. 33, no. 1, 1994, pp. 20-7.
Griffith DR, Azuma SD, Chasnoff IJ. Three-year outcome of children exposed prenatally to drugs. J Am Acad Child Adolesc Psychiatry. 1994;33(1):20-7.
Griffith, D. R., Azuma, S. D., & Chasnoff, I. J. (1994). Three-year outcome of children exposed prenatally to drugs. Journal of the American Academy of Child and Adolescent Psychiatry, 33(1), 20-7.
Griffith DR, Azuma SD, Chasnoff IJ. Three-year Outcome of Children Exposed Prenatally to Drugs. J Am Acad Child Adolesc Psychiatry. 1994;33(1):20-7. PubMed PMID: 7511139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three-year outcome of children exposed prenatally to drugs. AU - Griffith,D R, AU - Azuma,S D, AU - Chasnoff,I J, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 20 EP - 7 JF - Journal of the American Academy of Child and Adolescent Psychiatry JO - J Am Acad Child Adolesc Psychiatry VL - 33 IS - 1 N2 - OBJECTIVE: To evaluate the 3-year behavioral and developmental outcome of children prenatally exposed to maternal substances of abuse. METHOD: Ninety-three children exposed prenatally to cocaine and other drugs taken by the mother during pregnancy (Group 1), 24 polydrug/noncocaine exposed children (Group 2), and 25 nonexposed children (Group 3) were evaluated at 3 years of age as part of a longitudinal prospective study of the impact of intrauterine substance exposure on long-term outcome. The Stanford-Binet Intelligence Scale: Fourth Edition(SBIS) was administered by examiners blinded to the exposure background of the children, and a pediatrician performed a complete medical evaluation on all the children. The children's primary caregiver completed the Achenbach Child Behavior Checklist. Stepwise multiple regression procedures were used to determine the factors that best predicted 3-year growth, intelligence, and behavior. RESULTS: Groups 1 and 2 differed from Group 3 on head circumference. Group 1 scored lower than Group 3 on SBIS Verbal Reasoning. Group 2 scored Slower than Group 3 on SBIS Abstract/Visual Reasoning. Cocaine exposure predicted poor verbal reasoning. Marijuana exposure predicted poor abstract/visual reasoning. Examiner rating predicted intellectual outcome and caregiver ratings. Caregivers rated exposed children as more aggressive than nonexposed. CONCLUSION: Contrary to information in the popular media, not all substance-exposed children suffer the same poor prognosis. In fact, generalizations about the fate of drug-exposed children must await additional research into the outcome of the broader population of drug-exposed children, examining the roles of maternal and environmental factors across a variety of geographic locations and socioeconomic levels. SN - 0890-8567 UR - https://www.unboundmedicine.com/medline/citation/7511139/Three_year_outcome_of_children_exposed_prenatally_to_drugs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-8567(09)64141-1 DB - PRIME DP - Unbound Medicine ER -