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Current observations on sickle cell genotype in Nigeria.
East Afr Med J. 1993 Oct; 70(10):646-9.EA

Abstract

The haematological indices and clinical manifestations of sickle cell disease (SCD) patients were investigated in a combined group of male and female Nigerians, and the results were matched against those from non-SCD individuals. Haemoglobin concentrations (Hb), red blood cell count (RBC) and packed cell volume (PCV) were significantly lower in the haemoglobin SS (HbSS) individuals than in the haemoglobin AS (HbAS) and haemoglobin AA (HbAA) individuals. White cell count (WBC) was of course higher in the HbSS patients as was the foetal haemoglobin (HbF) also. The clinical investigations show a 16% incidence of leg ulceration amongst the SCD patients and a 25% incidence of 'crisis state' requiring blood transfusion. Comparison of these findings with those obtained for Jamaicans and Saudi Arabian sickle cell patients show several differences indicating a milder disease in the Nigerian than the Jamaicans.

Authors+Show Affiliations

Department of Chemical Pathology, University of Port Harcourt Teaching Hospital, River State, Nigeria.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7514527

Citation

Nduka, N, et al. "Current Observations On Sickle Cell Genotype in Nigeria." East African Medical Journal, vol. 70, no. 10, 1993, pp. 646-9.
Nduka N, Owhochuku SM, Odike P. Current observations on sickle cell genotype in Nigeria. East Afr Med J. 1993;70(10):646-9.
Nduka, N., Owhochuku, S. M., & Odike, P. (1993). Current observations on sickle cell genotype in Nigeria. East African Medical Journal, 70(10), 646-9.
Nduka N, Owhochuku SM, Odike P. Current Observations On Sickle Cell Genotype in Nigeria. East Afr Med J. 1993;70(10):646-9. PubMed PMID: 7514527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current observations on sickle cell genotype in Nigeria. AU - Nduka,N, AU - Owhochuku,S M, AU - Odike,P, PY - 1993/10/1/pubmed PY - 1993/10/1/medline PY - 1993/10/1/entrez SP - 646 EP - 9 JF - East African medical journal JO - East Afr Med J VL - 70 IS - 10 N2 - The haematological indices and clinical manifestations of sickle cell disease (SCD) patients were investigated in a combined group of male and female Nigerians, and the results were matched against those from non-SCD individuals. Haemoglobin concentrations (Hb), red blood cell count (RBC) and packed cell volume (PCV) were significantly lower in the haemoglobin SS (HbSS) individuals than in the haemoglobin AS (HbAS) and haemoglobin AA (HbAA) individuals. White cell count (WBC) was of course higher in the HbSS patients as was the foetal haemoglobin (HbF) also. The clinical investigations show a 16% incidence of leg ulceration amongst the SCD patients and a 25% incidence of 'crisis state' requiring blood transfusion. Comparison of these findings with those obtained for Jamaicans and Saudi Arabian sickle cell patients show several differences indicating a milder disease in the Nigerian than the Jamaicans. SN - 0012-835X UR - https://www.unboundmedicine.com/medline/citation/7514527/Current_observations_on_sickle_cell_genotype_in_Nigeria_ DB - PRIME DP - Unbound Medicine ER -