Tags

Type your tag names separated by a space and hit enter

Two-locus linkage analysis in multiple sclerosis (MS).
Genomics. 1994 Jan 15; 19(2):320-5.G

Abstract

One of the major challenges in genetic linkage analyses is the study of complex diseases. We demonstrate here the use of two-locus linkage analysis in multiple sclerosis (MS), a multifactorial disease with a complex mode of inheritance. In a set of Finnish multiplex families, we have previously found evidence for linkage between MS susceptibility and two independent loci, the myelin basic protein gene (MBP) on chromosome 18 and the HLA complex on chromosome 6. This set of families provides a unique opportunity to perform linkage analysis conditional on two loci contributing to the disease. In the two-trait-locus/two-marker-locus analysis, the presence of another disease locus is parametrized and the analysis more appropriately treats information from the unaffected family members than single-disease-locus analysis. As exemplified here in MS, the two-locus analysis can be a powerful method for investigating susceptibility loci in complex traits, best suited for analysis of specific candidate genes, or for situations in which preliminary evidence for linkage already exists or is suggested.

Authors+Show Affiliations

Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7514567

Citation

Tienari, P J., et al. "Two-locus Linkage Analysis in Multiple Sclerosis (MS)." Genomics, vol. 19, no. 2, 1994, pp. 320-5.
Tienari PJ, Terwilliger JD, Ott J, et al. Two-locus linkage analysis in multiple sclerosis (MS). Genomics. 1994;19(2):320-5.
Tienari, P. J., Terwilliger, J. D., Ott, J., Palo, J., & Peltonen, L. (1994). Two-locus linkage analysis in multiple sclerosis (MS). Genomics, 19(2), 320-5.
Tienari PJ, et al. Two-locus Linkage Analysis in Multiple Sclerosis (MS). Genomics. 1994 Jan 15;19(2):320-5. PubMed PMID: 7514567.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two-locus linkage analysis in multiple sclerosis (MS). AU - Tienari,P J, AU - Terwilliger,J D, AU - Ott,J, AU - Palo,J, AU - Peltonen,L, PY - 1994/1/15/pubmed PY - 1994/1/15/medline PY - 1994/1/15/entrez SP - 320 EP - 5 JF - Genomics JO - Genomics VL - 19 IS - 2 N2 - One of the major challenges in genetic linkage analyses is the study of complex diseases. We demonstrate here the use of two-locus linkage analysis in multiple sclerosis (MS), a multifactorial disease with a complex mode of inheritance. In a set of Finnish multiplex families, we have previously found evidence for linkage between MS susceptibility and two independent loci, the myelin basic protein gene (MBP) on chromosome 18 and the HLA complex on chromosome 6. This set of families provides a unique opportunity to perform linkage analysis conditional on two loci contributing to the disease. In the two-trait-locus/two-marker-locus analysis, the presence of another disease locus is parametrized and the analysis more appropriately treats information from the unaffected family members than single-disease-locus analysis. As exemplified here in MS, the two-locus analysis can be a powerful method for investigating susceptibility loci in complex traits, best suited for analysis of specific candidate genes, or for situations in which preliminary evidence for linkage already exists or is suggested. SN - 0888-7543 UR - https://www.unboundmedicine.com/medline/citation/7514567/Two_locus_linkage_analysis_in_multiple_sclerosis__MS__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0888-7543(84)71064-0 DB - PRIME DP - Unbound Medicine ER -