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Nature of the reactive epitopes in Paracoccidioides brasiliensis polysaccharide antigen.
J Med Vet Mycol. 1994; 32(1):77-81.JM

Abstract

Fava Nettos' polysaccharide antigen (FNPA), shown to detect humoral and cellular responses in paracoccidioidomycosis, was investigated. Skin tests with FNPA were negative after alkaline hydrolysis or depletion of gp43 peptide epitopes. Purified antibodies to FNPA or gp43 from paracoccidioidomycosis patients cross-reacted, showing common epitopes and FNPA-specific ones. Normal human sera, in contrast to paracoccidioidomycosis sera, were unreactive with gp43 but recognized epitopes of FNPA susceptible to alkaline hydrolysis and pronase treatment. Histoplasmosis patients sera strongly reacted with FNPA carbohydrate epitopes.

Authors+Show Affiliations

Rodrigues EG
Disciplina de Biologia Celular, Escola Paulista de Medicina, São Paulo, Brazil.
Travassos LR
No affiliation info available

MeSH

AnimalsAntibodies, FungalAntigens, FungalCross ReactionsEpitopesGuinea PigsHistoplasmosisHumansMaleParacoccidioidesParacoccidioidomycosisPolysaccharidesSkin Tests

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7515959

Citation

Rodrigues, E G., and L R. Travassos. "Nature of the Reactive Epitopes in Paracoccidioides Brasiliensis Polysaccharide Antigen." Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology, vol. 32, no. 1, 1994, pp. 77-81.
Rodrigues EG, Travassos LR. Nature of the reactive epitopes in Paracoccidioides brasiliensis polysaccharide antigen. J Med Vet Mycol. 1994;32(1):77-81.
Rodrigues, E. G., & Travassos, L. R. (1994). Nature of the reactive epitopes in Paracoccidioides brasiliensis polysaccharide antigen. Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology, 32(1), 77-81.
Rodrigues EG, Travassos LR. Nature of the Reactive Epitopes in Paracoccidioides Brasiliensis Polysaccharide Antigen. J Med Vet Mycol. 1994;32(1):77-81. PubMed PMID: 7515959.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nature of the reactive epitopes in Paracoccidioides brasiliensis polysaccharide antigen. AU - Rodrigues,E G, AU - Travassos,L R, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 77 EP - 81 JF - Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology JO - J Med Vet Mycol VL - 32 IS - 1 N2 - Fava Nettos' polysaccharide antigen (FNPA), shown to detect humoral and cellular responses in paracoccidioidomycosis, was investigated. Skin tests with FNPA were negative after alkaline hydrolysis or depletion of gp43 peptide epitopes. Purified antibodies to FNPA or gp43 from paracoccidioidomycosis patients cross-reacted, showing common epitopes and FNPA-specific ones. Normal human sera, in contrast to paracoccidioidomycosis sera, were unreactive with gp43 but recognized epitopes of FNPA susceptible to alkaline hydrolysis and pronase treatment. Histoplasmosis patients sera strongly reacted with FNPA carbohydrate epitopes. SN - 0268-1218 UR - https://www.unboundmedicine.com/medline/citation/7515959/Nature_of_the_reactive_epitopes_in_Paracoccidioides_brasiliensis_polysaccharide_antigen_ DB - PRIME DP - Unbound Medicine ER -