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The influence of Tołpa Peat Preparation (TPP) on rat liver regeneration.
Acta Pol Pharm 1993; 50(4-5):413-6AP

Abstract

The effect of Tolpa peat preparation (TPP) on the regenerative response has been examined in rats submitted to two thirds hepatectomy. The ornithine decarboxylase activity, spermidine and histamine levels, DNA and RNA content, RNA/DNA ratio and the mass of restituted liver were used to test the intensity of the regenerative processes. The action of TPP is dual: a short-term application of TPP at a dose of 20 mg/kg/day causes an inhibition of the ornithine decarboxylase activity, the decrease in spermidine formation, the levels of DNA and RNA, and liver restitution. The multiple application of TPP, on the other hand, results in a stimulation of ornithine decarboxylase, the increase in spermidine and histamine as well as RNA and DNA levels in regenerating liver; concomitantly, the liver mass tends to increase in TPP treated groups. TPP might exert its effects, at least partially, by interfering with polyamine biosynthesis.

Authors+Show Affiliations

Department of Biogenic Amines, Polish Academy of Sciences, Lódź.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7518639

Citation

Maśliński, C, et al. "The Influence of Tołpa Peat Preparation (TPP) On Rat Liver Regeneration." Acta Poloniae Pharmaceutica, vol. 50, no. 4-5, 1993, pp. 413-6.
Maśliński C, Fogel WA, Andrzejewski W. The influence of Tołpa Peat Preparation (TPP) on rat liver regeneration. Acta Pol Pharm. 1993;50(4-5):413-6.
Maśliński, C., Fogel, W. A., & Andrzejewski, W. (1993). The influence of Tołpa Peat Preparation (TPP) on rat liver regeneration. Acta Poloniae Pharmaceutica, 50(4-5), pp. 413-6.
Maśliński C, Fogel WA, Andrzejewski W. The Influence of Tołpa Peat Preparation (TPP) On Rat Liver Regeneration. Acta Pol Pharm. 1993;50(4-5):413-6. PubMed PMID: 7518639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of Tołpa Peat Preparation (TPP) on rat liver regeneration. AU - Maśliński,C, AU - Fogel,W A, AU - Andrzejewski,W, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 413 EP - 6 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 50 IS - 4-5 N2 - The effect of Tolpa peat preparation (TPP) on the regenerative response has been examined in rats submitted to two thirds hepatectomy. The ornithine decarboxylase activity, spermidine and histamine levels, DNA and RNA content, RNA/DNA ratio and the mass of restituted liver were used to test the intensity of the regenerative processes. The action of TPP is dual: a short-term application of TPP at a dose of 20 mg/kg/day causes an inhibition of the ornithine decarboxylase activity, the decrease in spermidine formation, the levels of DNA and RNA, and liver restitution. The multiple application of TPP, on the other hand, results in a stimulation of ornithine decarboxylase, the increase in spermidine and histamine as well as RNA and DNA levels in regenerating liver; concomitantly, the liver mass tends to increase in TPP treated groups. TPP might exert its effects, at least partially, by interfering with polyamine biosynthesis. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/7518639/The_influence_of_Tołpa_Peat_Preparation__TPP__on_rat_liver_regeneration_ DB - PRIME DP - Unbound Medicine ER -