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Evaluation of the sensitivity, specificity, and predictive value of monoclonal antibody 3F6 for the detection of Pneumocystis carinii pneumonia in bronchoalveolar lavage specimens and induced sputum.
Cytopathology. 1994 Apr; 5(2):82-9.C

Abstract

The sensitivity and specificity of different staining procedures for the detection of Pneumocystis carinii organisms were compared. Three conventional stains (Papanicolaou, Giemsa and Grocott's) and one immunocytochemical stain using 3F6 antibody were used on smears prepared from the same specimen. Bronchoalveolar lavage (BAL) and induced sputum (IS) specimens were used for this purpose. One hundred and sixty-five episodes from 142 patients were investigated by the four different staining techniques. Cysts of P. carinii were detected in 64 episodes from 63 patients. Immunocytochemical staining with 3F6 was found to be slightly more sensitive at detecting the cysts than Grocott's, Giemsa, or Papanicolaou stain.

Authors+Show Affiliations

Department of Cytopathology, Saint Mary's Hospital, London, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7518707

Citation

Wazir, J F., et al. "Evaluation of the Sensitivity, Specificity, and Predictive Value of Monoclonal Antibody 3F6 for the Detection of Pneumocystis Carinii Pneumonia in Bronchoalveolar Lavage Specimens and Induced Sputum." Cytopathology : Official Journal of the British Society for Clinical Cytology, vol. 5, no. 2, 1994, pp. 82-9.
Wazir JF, Macrorie SG, Coleman DV. Evaluation of the sensitivity, specificity, and predictive value of monoclonal antibody 3F6 for the detection of Pneumocystis carinii pneumonia in bronchoalveolar lavage specimens and induced sputum. Cytopathology. 1994;5(2):82-9.
Wazir, J. F., Macrorie, S. G., & Coleman, D. V. (1994). Evaluation of the sensitivity, specificity, and predictive value of monoclonal antibody 3F6 for the detection of Pneumocystis carinii pneumonia in bronchoalveolar lavage specimens and induced sputum. Cytopathology : Official Journal of the British Society for Clinical Cytology, 5(2), 82-9.
Wazir JF, Macrorie SG, Coleman DV. Evaluation of the Sensitivity, Specificity, and Predictive Value of Monoclonal Antibody 3F6 for the Detection of Pneumocystis Carinii Pneumonia in Bronchoalveolar Lavage Specimens and Induced Sputum. Cytopathology. 1994;5(2):82-9. PubMed PMID: 7518707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the sensitivity, specificity, and predictive value of monoclonal antibody 3F6 for the detection of Pneumocystis carinii pneumonia in bronchoalveolar lavage specimens and induced sputum. AU - Wazir,J F, AU - Macrorie,S G, AU - Coleman,D V, PY - 1994/4/1/pubmed PY - 1994/4/1/medline PY - 1994/4/1/entrez SP - 82 EP - 9 JF - Cytopathology : official journal of the British Society for Clinical Cytology JO - Cytopathology VL - 5 IS - 2 N2 - The sensitivity and specificity of different staining procedures for the detection of Pneumocystis carinii organisms were compared. Three conventional stains (Papanicolaou, Giemsa and Grocott's) and one immunocytochemical stain using 3F6 antibody were used on smears prepared from the same specimen. Bronchoalveolar lavage (BAL) and induced sputum (IS) specimens were used for this purpose. One hundred and sixty-five episodes from 142 patients were investigated by the four different staining techniques. Cysts of P. carinii were detected in 64 episodes from 63 patients. Immunocytochemical staining with 3F6 was found to be slightly more sensitive at detecting the cysts than Grocott's, Giemsa, or Papanicolaou stain. SN - 0956-5507 UR - https://www.unboundmedicine.com/medline/citation/7518707/Evaluation_of_the_sensitivity_specificity_and_predictive_value_of_monoclonal_antibody_3F6_for_the_detection_of_Pneumocystis_carinii_pneumonia_in_bronchoalveolar_lavage_specimens_and_induced_sputum_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0956-5507&date=1994&volume=5&issue=2&spage=82 DB - PRIME DP - Unbound Medicine ER -