Tags

Type your tag names separated by a space and hit enter

Influence of Tołpa Peat Preparation on the IgE-induced anaphylactic reactions in mice.
Acta Pol Pharm 1993; 50(6):475-80AP

Abstract

The ability of Tołpa Peat Preparation (TPP) to affect anaphylactic sensitization and mast cell secretory function was tested in BALB/c mice treated with TPP orally for 12 days. TPP in the doses of 20 and 50 mg/kg/day reduced histamine release from mouse peritoneal mast cells challenged with anti-IgE or concanavalin A in vitro. The treatment of mice with TPP from day 1 to day 12 of immunization with Ovalbumin (OA) absorbed on aluminium hydroxide gel resulted in a decrease of antigen-induced histamine release from mast cells of these mice in vitro and in decreased IgE antibody level in their sera. TPP introduced into OA-immunized mice showing developed IgE antibody response was less effective in decreasing anaphylactic histamine release from mast cells of these mice. In all experiments low doses of TPP used for oral treatment were more effective than high doses in inhibiting anaphylactic events in the mice.

Authors+Show Affiliations

Department of Biogenic Amines, Polish Academy of Sciences, Lódź.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7520662

Citation

Wyczółkowska, J, et al. "Influence of Tołpa Peat Preparation On the IgE-induced Anaphylactic Reactions in Mice." Acta Poloniae Pharmaceutica, vol. 50, no. 6, 1993, pp. 475-80.
Wyczółkowska J, Michoń T, Slusarczyk A, et al. Influence of Tołpa Peat Preparation on the IgE-induced anaphylactic reactions in mice. Acta Pol Pharm. 1993;50(6):475-80.
Wyczółkowska, J., Michoń, T., Slusarczyk, A., Kolago, B., & Maśliński, C. (1993). Influence of Tołpa Peat Preparation on the IgE-induced anaphylactic reactions in mice. Acta Poloniae Pharmaceutica, 50(6), pp. 475-80.
Wyczółkowska J, et al. Influence of Tołpa Peat Preparation On the IgE-induced Anaphylactic Reactions in Mice. Acta Pol Pharm. 1993;50(6):475-80. PubMed PMID: 7520662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of Tołpa Peat Preparation on the IgE-induced anaphylactic reactions in mice. AU - Wyczółkowska,J, AU - Michoń,T, AU - Slusarczyk,A, AU - Kolago,B, AU - Maśliński,C, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 475 EP - 80 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 50 IS - 6 N2 - The ability of Tołpa Peat Preparation (TPP) to affect anaphylactic sensitization and mast cell secretory function was tested in BALB/c mice treated with TPP orally for 12 days. TPP in the doses of 20 and 50 mg/kg/day reduced histamine release from mouse peritoneal mast cells challenged with anti-IgE or concanavalin A in vitro. The treatment of mice with TPP from day 1 to day 12 of immunization with Ovalbumin (OA) absorbed on aluminium hydroxide gel resulted in a decrease of antigen-induced histamine release from mast cells of these mice in vitro and in decreased IgE antibody level in their sera. TPP introduced into OA-immunized mice showing developed IgE antibody response was less effective in decreasing anaphylactic histamine release from mast cells of these mice. In all experiments low doses of TPP used for oral treatment were more effective than high doses in inhibiting anaphylactic events in the mice. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/7520662/Influence_of_Tołpa_Peat_Preparation_on_the_IgE_induced_anaphylactic_reactions_in_mice_ L2 - https://medlineplus.gov/anaphylaxis.html DB - PRIME DP - Unbound Medicine ER -