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[4-Aminopyridine induced histamine release and its antagonism by certain drugs].
Yao Xue Xue Bao. 1994; 29(3):176-9.YX

Abstract

4-Aminopyridine (4-AP), a known potassium channel blocker, was shown to induce histamine release from mast cells in mice. After ip 4-AP 5 mg.kg-1 the histamine content increased in blood, but decreased in the lung tissue. Calcium antagonists nifedipine (NIF) 500 mg.kg-1 ig, TMB-8 300 mumol.L-1 in vitro and potassium channel opener minoxidil (MIN) 100 mg.kg-1 inhibited the histamine release induced by 4-AP from mouse peritoneal mast cells (PMC). These results provide evidence that potassium channels are present in mouse mast cell membranes and indicate that the mechanism of histamine release by 4-AP may be related to the potassium channel blocking effect. As the result of this effect, the calcium channels open and the Ca2+ influx to the mast cells increases, thus eliciting histamine release.

Authors+Show Affiliations

Xu JH
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Zhejiang Medical University, Hangzhou.
Wu HS
No affiliation info available
Li L
No affiliation info available

MeSH

4-AminopyridineAnimalsCalcium Channel BlockersFemaleGallic AcidHistamineHistamine ReleaseLungMaleMast CellsMiceMinoxidilNifedipine

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

7521560

Citation

Xu, J H., et al. "[4-Aminopyridine Induced Histamine Release and Its Antagonism By Certain Drugs]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 29, no. 3, 1994, pp. 176-9.
Xu JH, Wu HS, Li L. [4-Aminopyridine induced histamine release and its antagonism by certain drugs]. Yao Xue Xue Bao. 1994;29(3):176-9.
Xu, J. H., Wu, H. S., & Li, L. (1994). [4-Aminopyridine induced histamine release and its antagonism by certain drugs]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 29(3), 176-9.
Xu JH, Wu HS, Li L. [4-Aminopyridine Induced Histamine Release and Its Antagonism By Certain Drugs]. Yao Xue Xue Bao. 1994;29(3):176-9. PubMed PMID: 7521560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [4-Aminopyridine induced histamine release and its antagonism by certain drugs]. AU - Xu,J H, AU - Wu,H S, AU - Li,L, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 176 EP - 9 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 29 IS - 3 N2 - 4-Aminopyridine (4-AP), a known potassium channel blocker, was shown to induce histamine release from mast cells in mice. After ip 4-AP 5 mg.kg-1 the histamine content increased in blood, but decreased in the lung tissue. Calcium antagonists nifedipine (NIF) 500 mg.kg-1 ig, TMB-8 300 mumol.L-1 in vitro and potassium channel opener minoxidil (MIN) 100 mg.kg-1 inhibited the histamine release induced by 4-AP from mouse peritoneal mast cells (PMC). These results provide evidence that potassium channels are present in mouse mast cell membranes and indicate that the mechanism of histamine release by 4-AP may be related to the potassium channel blocking effect. As the result of this effect, the calcium channels open and the Ca2+ influx to the mast cells increases, thus eliciting histamine release. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/7521560/[4_Aminopyridine_induced_histamine_release_and_its_antagonism_by_certain_drugs]_ L2 - https://antibodies.cancer.gov/detail/CPTC-S100A9-1 DB - PRIME DP - Unbound Medicine ER -