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Influence of DPPE on histamine release from isolated rat mast cells.
Agents Actions. 1994 Mar; 41(1-2):1-4.AA

Abstract

A second messenger function for histamine has been proposed based on the effects of the anti-estrogen drug DPPE (N,N-diethyl-2-(4-(phenylmethyl)phenoxy) ethanamine.HCl). The ability of DPPE to inhibit concanavalin A-induced histamine release led to the present investigation of its influence on the mast cell response to a wider selection of secretagogues. DPPE was an efficient inhibitor of antigen-induced release, while responses to compound 48/80 were virtually unaffected. Responses to the ionophore A23187 could be enhanced as well as inhibited, whereas the influence of DPPE on the combination of the ionophore and the phorbol ester TPA was variable and small. These results seem to exclude an involvement of a DPPE-sensitive histamine-mediated signal system of common importance in mast cell histamine release.

Authors+Show Affiliations

Grosman N
Department of Pharmacology, Panum Institute, University of Copenhagen, Denmark.

MeSH

AnimalsCalcimycinHistamine AntagonistsHistamine ReleaseIn Vitro TechniquesMaleMast CellsPhenyl EthersRatsRats, WistarSecond Messenger Systemsp-Methoxy-N-methylphenethylamine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7521567

Citation

Grosman, N. "Influence of DPPE On Histamine Release From Isolated Rat Mast Cells." Agents and Actions, vol. 41, no. 1-2, 1994, pp. 1-4.
Grosman N. Influence of DPPE on histamine release from isolated rat mast cells. Agents Actions. 1994;41(1-2):1-4.
Grosman, N. (1994). Influence of DPPE on histamine release from isolated rat mast cells. Agents and Actions, 41(1-2), 1-4.
Grosman N. Influence of DPPE On Histamine Release From Isolated Rat Mast Cells. Agents Actions. 1994;41(1-2):1-4. PubMed PMID: 7521567.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of DPPE on histamine release from isolated rat mast cells. A1 - Grosman,N, PY - 1994/3/1/pubmed PY - 1994/3/1/medline PY - 1994/3/1/entrez SP - 1 EP - 4 JF - Agents and actions JO - Agents Actions VL - 41 IS - 1-2 N2 - A second messenger function for histamine has been proposed based on the effects of the anti-estrogen drug DPPE (N,N-diethyl-2-(4-(phenylmethyl)phenoxy) ethanamine.HCl). The ability of DPPE to inhibit concanavalin A-induced histamine release led to the present investigation of its influence on the mast cell response to a wider selection of secretagogues. DPPE was an efficient inhibitor of antigen-induced release, while responses to compound 48/80 were virtually unaffected. Responses to the ionophore A23187 could be enhanced as well as inhibited, whereas the influence of DPPE on the combination of the ionophore and the phorbol ester TPA was variable and small. These results seem to exclude an involvement of a DPPE-sensitive histamine-mediated signal system of common importance in mast cell histamine release. SN - 0065-4299 UR - https://www.unboundmedicine.com/medline/citation/7521567/Influence_of_DPPE_on_histamine_release_from_isolated_rat_mast_cells_ L2 - https://medlineplus.gov/coldandcoughmedicines.html DB - PRIME DP - Unbound Medicine ER -