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Endotoxin is angiogenic.
Int J Exp Pathol. 1994 Jun; 75(3):191-6.IJ

Abstract

The formation of new blood vessels, angiogenesis, is an important event in inflammation, wound healing and tumour growth. Mediators produced by various cells when exposed to endotoxin include cytokines (tumour necrosis factor, interleukins 1 and 6, and basic fibroblast growth factor) which, it has been suggested, stimulate angiogenesis. The angiogenic effect of endotoxin (lipopolysaccharide, LPS) was studied in rats using the quantitative mesenteric window assay. Adult rats were injected intraperitoneally with Escherichia coli LPS (5 pg/ml-20,000 ng/ml) twice daily for 4.5 consecutive days and were sacrificed 14 days after the start of this treatment. An angiogenic response was observed at concentrations of > 2 ng/ml in a dose-dependent manner. No inflammatory cellular exudate was seen in the test tissue at the time of angiogenesis analysis. Suppressed body-weight gain, a marker of the systemic effect of LPS in the rat, was significant only at the highest dose tested. The data suggest that endotoxin-mediated neovascularization could be a component of inflammation and wound healing.

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Authors+Show Affiliations

Mattsby-Baltzer I
Department of Clinical Bacteriology, University of Göteborg, Sweden.
Jakobsson A
No affiliation info available
Sörbo J
No affiliation info available
Norrby K
No affiliation info available

MeSH

AnimalsDose-Response Relationship, DrugEndotoxinsEscherichia coliHistamine ReleaseLipopolysaccharidesMaleMast CellsMesenteryNeovascularization, PathologicPhotographyRatsRats, Sprague-DawleyWeight Gain

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7522030

Citation

Mattsby-Baltzer, I, et al. "Endotoxin Is Angiogenic." International Journal of Experimental Pathology, vol. 75, no. 3, 1994, pp. 191-6.
Mattsby-Baltzer I, Jakobsson A, Sörbo J, et al. Endotoxin is angiogenic. Int J Exp Pathol. 1994;75(3):191-6.
Mattsby-Baltzer, I., Jakobsson, A., Sörbo, J., & Norrby, K. (1994). Endotoxin is angiogenic. International Journal of Experimental Pathology, 75(3), 191-6.
Mattsby-Baltzer I, et al. Endotoxin Is Angiogenic. Int J Exp Pathol. 1994;75(3):191-6. PubMed PMID: 7522030.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endotoxin is angiogenic. AU - Mattsby-Baltzer,I, AU - Jakobsson,A, AU - Sörbo,J, AU - Norrby,K, PY - 1994/6/1/pubmed PY - 1994/6/1/medline PY - 1994/6/1/entrez SP - 191 EP - 6 JF - International journal of experimental pathology JO - Int J Exp Pathol VL - 75 IS - 3 N2 - The formation of new blood vessels, angiogenesis, is an important event in inflammation, wound healing and tumour growth. Mediators produced by various cells when exposed to endotoxin include cytokines (tumour necrosis factor, interleukins 1 and 6, and basic fibroblast growth factor) which, it has been suggested, stimulate angiogenesis. The angiogenic effect of endotoxin (lipopolysaccharide, LPS) was studied in rats using the quantitative mesenteric window assay. Adult rats were injected intraperitoneally with Escherichia coli LPS (5 pg/ml-20,000 ng/ml) twice daily for 4.5 consecutive days and were sacrificed 14 days after the start of this treatment. An angiogenic response was observed at concentrations of > 2 ng/ml in a dose-dependent manner. No inflammatory cellular exudate was seen in the test tissue at the time of angiogenesis analysis. Suppressed body-weight gain, a marker of the systemic effect of LPS in the rat, was significant only at the highest dose tested. The data suggest that endotoxin-mediated neovascularization could be a component of inflammation and wound healing. SN - 0959-9673 UR - https://www.unboundmedicine.com/medline/citation/7522030/Endotoxin_is_angiogenic_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0959-9673&date=1994&volume=75&issue=3&spage=191 DB - PRIME DP - Unbound Medicine ER -