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[Comparison of 2 6% middle-molecular hydroxyethyl starch solutions on elimination kinetics and flow characteristics of blood in volunteers].
Infusionsther Transfusionsmed. 1994 Aug; 21(4):251-9.IT

Abstract

OBJECTIVE

Investigation of the influence of C2/C6 occupation ratio of 2 different 6% hydroxyethyl starch (HES) solutions on elimination kinetics and blood fluidity.

DESIGN

A single-blinded, prospective randomised cross-over study.

SETTING

Haemostasiological-angiologic outpatient department of the university of Homburg.

SUBJECTS

6 voluntary apparently healthy subjects.

INTERVENTIONS

A 500 ml infusion of 2 different HES solutions (6% HES 200/0.5 or 6% HES 200/0.62, respectively) was given intravenously within 1 h. A wash-out phase of 3 months was kept between both infusions. The concentration and distribution of the molecular weight of the intravasal HES molecules up until 24 h after the infusion as well as the blood fluidity before and after the infusion were measured.

RESULTS

Besides the molecular substitution (MS), which is different for the 2 employed HES solutions, the occupation ratio of the C2 respectively C6 (C2/C6 occupation ratio) of the glucose ring influences the breakdown of the HES molecules. This influences the blood fluidity. While the decrease in haematocrit 1 h after the end of the infusion is comparable, the decrease in the haematocrit in the case of high C2/C6 occupation ratio and a high MS is maintained for a longer period of time. The increase in plasma viscosity in the case of high C2/C6 occupation ratio and high MS is more marked.

CONCLUSIONS

The infusion of HES 200/0.62 leads to a significantly longer prevalence in comparison to HES 200/0.5, in combination with clearly larger degradation products in the plasma; this fact causes a more marked dilutional effect, but also a more marked increase in the plasma viscosity up to 24 h after the end of infusion. In the discussion on haemodilution therapy in patients with arterial occlusive disease the employment of HES which induces an increase in plasma viscosity is thought to be a disadvantage.

Authors+Show Affiliations

Abteilung für klinische Hämostaseologie und Transfusionsmedizin, Universitätskliniken des Saarlandes, Homburg/Saar.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

ger

PubMed ID

7524833

Citation

Koscielny, J, et al. "[Comparison of 2 6% Middle-molecular Hydroxyethyl Starch Solutions On Elimination Kinetics and Flow Characteristics of Blood in Volunteers]." Infusionstherapie Und Transfusionsmedizin, vol. 21, no. 4, 1994, pp. 251-9.
Koscielny J, Jung F, Mrowietz C, et al. [Comparison of 2 6% middle-molecular hydroxyethyl starch solutions on elimination kinetics and flow characteristics of blood in volunteers]. Infusionsther Transfusionsmed. 1994;21(4):251-9.
Koscielny, J., Jung, F., Mrowietz, C., Pindur, G., Förster, H., Schimetta, W., Kiesewetter, H., & Wenzel, E. (1994). [Comparison of 2 6% middle-molecular hydroxyethyl starch solutions on elimination kinetics and flow characteristics of blood in volunteers]. Infusionstherapie Und Transfusionsmedizin, 21(4), 251-9.
Koscielny J, et al. [Comparison of 2 6% Middle-molecular Hydroxyethyl Starch Solutions On Elimination Kinetics and Flow Characteristics of Blood in Volunteers]. Infusionsther Transfusionsmed. 1994;21(4):251-9. PubMed PMID: 7524833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparison of 2 6% middle-molecular hydroxyethyl starch solutions on elimination kinetics and flow characteristics of blood in volunteers]. AU - Koscielny,J, AU - Jung,F, AU - Mrowietz,C, AU - Pindur,G, AU - Förster,H, AU - Schimetta,W, AU - Kiesewetter,H, AU - Wenzel,E, PY - 1994/8/1/pubmed PY - 1994/8/1/medline PY - 1994/8/1/entrez SP - 251 EP - 9 JF - Infusionstherapie und Transfusionsmedizin JO - Infusionsther Transfusionsmed VL - 21 IS - 4 N2 - OBJECTIVE: Investigation of the influence of C2/C6 occupation ratio of 2 different 6% hydroxyethyl starch (HES) solutions on elimination kinetics and blood fluidity. DESIGN: A single-blinded, prospective randomised cross-over study. SETTING: Haemostasiological-angiologic outpatient department of the university of Homburg. SUBJECTS: 6 voluntary apparently healthy subjects. INTERVENTIONS: A 500 ml infusion of 2 different HES solutions (6% HES 200/0.5 or 6% HES 200/0.62, respectively) was given intravenously within 1 h. A wash-out phase of 3 months was kept between both infusions. The concentration and distribution of the molecular weight of the intravasal HES molecules up until 24 h after the infusion as well as the blood fluidity before and after the infusion were measured. RESULTS: Besides the molecular substitution (MS), which is different for the 2 employed HES solutions, the occupation ratio of the C2 respectively C6 (C2/C6 occupation ratio) of the glucose ring influences the breakdown of the HES molecules. This influences the blood fluidity. While the decrease in haematocrit 1 h after the end of the infusion is comparable, the decrease in the haematocrit in the case of high C2/C6 occupation ratio and a high MS is maintained for a longer period of time. The increase in plasma viscosity in the case of high C2/C6 occupation ratio and high MS is more marked. CONCLUSIONS: The infusion of HES 200/0.62 leads to a significantly longer prevalence in comparison to HES 200/0.5, in combination with clearly larger degradation products in the plasma; this fact causes a more marked dilutional effect, but also a more marked increase in the plasma viscosity up to 24 h after the end of infusion. In the discussion on haemodilution therapy in patients with arterial occlusive disease the employment of HES which induces an increase in plasma viscosity is thought to be a disadvantage. SN - 1019-8466 UR - https://www.unboundmedicine.com/medline/citation/7524833/[Comparison_of_2_6_middle_molecular_hydroxyethyl_starch_solutions_on_elimination_kinetics_and_flow_characteristics_of_blood_in_volunteers]_ DB - PRIME DP - Unbound Medicine ER -