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The prognostic significance of urinary beta core fragment in premenopausal women with carcinoma of the cervix.
Gynecol Oncol. 1994 Nov; 55(2):271-6.GO

Abstract

The mortality of premenopausal women with cervical carcinoma has increased in recent decades despite attempts to provide screening. The urinary concentration of the beta core fragment of hCG has been proposed as a sensitive marker in gynecological malignancies, although most studies have not corrected for urine concentration. We measured the urinary concentration of beta core and creatinine in 61 women who developed cervical cancer premenopausally and expressed the concentration of beta core per millimole of creatinine using the 90th percentile of a control group as a cutoff level. While correcting for urinary concentration results in a reduction in sensitivity of the test (67 to 51%), there is improved correlation with prognosis in that after 18 months 81% of women positive for beta core had died, while 80% of women negative for beta core were still alive. Of those initially presenting and dying there was an increase with increasing stage of disease. For patients with initial presentation disease, 11 (79%) of the 14 patients with elevated levels had died compared with 1 of 21 (5%) who were negative for beta core. Urinary beta core fragment may have a major role as a prognostic indicator in cervical carcinoma rather than as a screening or diagnostic marker and enables identification of patients at higher risk of an aggressive disease.

Authors+Show Affiliations

Williamson Laboratory for Molecular Oncology, Medical College, St. Bartholomew's Hospital (University of London), West Smithfield, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7525427

Citation

Carter, P G., et al. "The Prognostic Significance of Urinary Beta Core Fragment in Premenopausal Women With Carcinoma of the Cervix." Gynecologic Oncology, vol. 55, no. 2, 1994, pp. 271-6.
Carter PG, Iles RK, Neven P, et al. The prognostic significance of urinary beta core fragment in premenopausal women with carcinoma of the cervix. Gynecol Oncol. 1994;55(2):271-6.
Carter, P. G., Iles, R. K., Neven, P., Ind, T. E., Shepherd, J. H., & Chard, T. (1994). The prognostic significance of urinary beta core fragment in premenopausal women with carcinoma of the cervix. Gynecologic Oncology, 55(2), 271-6.
Carter PG, et al. The Prognostic Significance of Urinary Beta Core Fragment in Premenopausal Women With Carcinoma of the Cervix. Gynecol Oncol. 1994;55(2):271-6. PubMed PMID: 7525427.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prognostic significance of urinary beta core fragment in premenopausal women with carcinoma of the cervix. AU - Carter,P G, AU - Iles,R K, AU - Neven,P, AU - Ind,T E, AU - Shepherd,J H, AU - Chard,T, PY - 1994/11/1/pubmed PY - 1994/11/1/medline PY - 1994/11/1/entrez SP - 271 EP - 6 JF - Gynecologic oncology JO - Gynecol Oncol VL - 55 IS - 2 N2 - The mortality of premenopausal women with cervical carcinoma has increased in recent decades despite attempts to provide screening. The urinary concentration of the beta core fragment of hCG has been proposed as a sensitive marker in gynecological malignancies, although most studies have not corrected for urine concentration. We measured the urinary concentration of beta core and creatinine in 61 women who developed cervical cancer premenopausally and expressed the concentration of beta core per millimole of creatinine using the 90th percentile of a control group as a cutoff level. While correcting for urinary concentration results in a reduction in sensitivity of the test (67 to 51%), there is improved correlation with prognosis in that after 18 months 81% of women positive for beta core had died, while 80% of women negative for beta core were still alive. Of those initially presenting and dying there was an increase with increasing stage of disease. For patients with initial presentation disease, 11 (79%) of the 14 patients with elevated levels had died compared with 1 of 21 (5%) who were negative for beta core. Urinary beta core fragment may have a major role as a prognostic indicator in cervical carcinoma rather than as a screening or diagnostic marker and enables identification of patients at higher risk of an aggressive disease. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/7525427/The_prognostic_significance_of_urinary_beta_core_fragment_in_premenopausal_women_with_carcinoma_of_the_cervix_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(84)71289-3 DB - PRIME DP - Unbound Medicine ER -