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[4-Aminopyridine-induced licking response and histamine liberation in mice].
Zhongguo Yao Li Xue Bao. 1994 May; 15(3):249-52.ZY

Abstract

4-Aminopyridine (4-AP) 1 mg.kg-1 sc at the scruff induced a licking response in mice. H1 receptor blockaders, such as diphenhydramine HCl (1, 10 mg.kg-1, sc at the scruff or 40 mg.kg-1, i.p.), chlorphenamine maleate (20 mg.kg-1, i.p.), and astemizole (2 mg.kg-1, i.g.), inhibited the licking response caused by 4-AP. Repeated injections of 4-AP (1 mg.kg-1) reduced the times of lick and the histamine content in the skin of injected site. 4-AP also promoted histamine release from incubated mouse peritoneal mast cells (PMC) in a dose-dependent manner. The results indicate that the licking response may originate from the histamine liberation of mast cells.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Zhejiang Medical University, Hangzhou, China.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

7526601

Citation

Lin, Y H., and J H. Xu. "[4-Aminopyridine-induced Licking Response and Histamine Liberation in Mice]." Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, vol. 15, no. 3, 1994, pp. 249-52.
Lin YH, Xu JH. [4-Aminopyridine-induced licking response and histamine liberation in mice]. Zhongguo Yao Li Xue Bao. 1994;15(3):249-52.
Lin, Y. H., & Xu, J. H. (1994). [4-Aminopyridine-induced licking response and histamine liberation in mice]. Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, 15(3), 249-52.
Lin YH, Xu JH. [4-Aminopyridine-induced Licking Response and Histamine Liberation in Mice]. Zhongguo Yao Li Xue Bao. 1994;15(3):249-52. PubMed PMID: 7526601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [4-Aminopyridine-induced licking response and histamine liberation in mice]. AU - Lin,Y H, AU - Xu,J H, PY - 1994/5/1/pubmed PY - 1994/5/1/medline PY - 1994/5/1/entrez SP - 249 EP - 52 JF - Zhongguo yao li xue bao = Acta pharmacologica Sinica JO - Zhongguo Yao Li Xue Bao VL - 15 IS - 3 N2 - 4-Aminopyridine (4-AP) 1 mg.kg-1 sc at the scruff induced a licking response in mice. H1 receptor blockaders, such as diphenhydramine HCl (1, 10 mg.kg-1, sc at the scruff or 40 mg.kg-1, i.p.), chlorphenamine maleate (20 mg.kg-1, i.p.), and astemizole (2 mg.kg-1, i.g.), inhibited the licking response caused by 4-AP. Repeated injections of 4-AP (1 mg.kg-1) reduced the times of lick and the histamine content in the skin of injected site. 4-AP also promoted histamine release from incubated mouse peritoneal mast cells (PMC) in a dose-dependent manner. The results indicate that the licking response may originate from the histamine liberation of mast cells. SN - 0253-9756 UR - https://www.unboundmedicine.com/medline/citation/7526601/[4_Aminopyridine_induced_licking_response_and_histamine_liberation_in_mice]_ L2 - http://www.chinaphar.com/1671-4083/15/249.pdf DB - PRIME DP - Unbound Medicine ER -