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Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein.
Ann Neurol. 1995 Feb; 37(2):211-7.AN

Abstract

Both apolipoprotein E and its receptor, the low-density-lipoprotein receptor-related protein (LRP), are associated with senile plaques in Alzheimer's disease. We examined the relationship of other LRP-related molecules to senile plaques. LRP is a multifunctional receptor that binds and rapidly internalizes at least seven ligands: apolipoprotein E, activated alpha 2-macroglobulin, tissue and urokinase-type plasminogen activators, plasminogen activator inhibitor-1, lipoprotein lipase, and lactoferrin. Using immunohistochemistry, we showed that all of these ligands, representing a diverse group of otherwise apparently unrelated proteins, accumulate on senile plaques. We also studied expression of the receptor-associated protein, a physiological inhibitor of LRP, in the hippocampal formation from normal subjects and Alzheimer's disease patients. Receptor-associated protein colocalizes with LRP on neuronal soma, but not on neuronal processes or reactive astrocytes. It is not present on senile plaques. These results suggest that senile plaque-associated LRP can bind its ligands, but clearance of these compounds may be impaired in the vicinity of senile plaques.

Authors+Show Affiliations

Department of Neurology, Masschusetts General Hospital, Boston 02114.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7531418

Citation

Rebeck, G W., et al. "Multiple, Diverse Senile Plaque-associated Proteins Are Ligands of an Apolipoprotein E Receptor, the Alpha 2-macroglobulin Receptor/low-density-lipoprotein Receptor-related Protein." Annals of Neurology, vol. 37, no. 2, 1995, pp. 211-7.
Rebeck GW, Harr SD, Strickland DK, et al. Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein. Ann Neurol. 1995;37(2):211-7.
Rebeck, G. W., Harr, S. D., Strickland, D. K., & Hyman, B. T. (1995). Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein. Annals of Neurology, 37(2), 211-7.
Rebeck GW, et al. Multiple, Diverse Senile Plaque-associated Proteins Are Ligands of an Apolipoprotein E Receptor, the Alpha 2-macroglobulin Receptor/low-density-lipoprotein Receptor-related Protein. Ann Neurol. 1995;37(2):211-7. PubMed PMID: 7531418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein. AU - Rebeck,G W, AU - Harr,S D, AU - Strickland,D K, AU - Hyman,B T, PY - 1995/2/1/pubmed PY - 1995/2/1/medline PY - 1995/2/1/entrez SP - 211 EP - 7 JF - Annals of neurology JO - Ann Neurol VL - 37 IS - 2 N2 - Both apolipoprotein E and its receptor, the low-density-lipoprotein receptor-related protein (LRP), are associated with senile plaques in Alzheimer's disease. We examined the relationship of other LRP-related molecules to senile plaques. LRP is a multifunctional receptor that binds and rapidly internalizes at least seven ligands: apolipoprotein E, activated alpha 2-macroglobulin, tissue and urokinase-type plasminogen activators, plasminogen activator inhibitor-1, lipoprotein lipase, and lactoferrin. Using immunohistochemistry, we showed that all of these ligands, representing a diverse group of otherwise apparently unrelated proteins, accumulate on senile plaques. We also studied expression of the receptor-associated protein, a physiological inhibitor of LRP, in the hippocampal formation from normal subjects and Alzheimer's disease patients. Receptor-associated protein colocalizes with LRP on neuronal soma, but not on neuronal processes or reactive astrocytes. It is not present on senile plaques. These results suggest that senile plaque-associated LRP can bind its ligands, but clearance of these compounds may be impaired in the vicinity of senile plaques. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/7531418/Multiple_diverse_senile_plaque_associated_proteins_are_ligands_of_an_apolipoprotein_E_receptor_the_alpha_2_macroglobulin_receptor/low_density_lipoprotein_receptor_related_protein_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1995&volume=37&issue=2&spage=211 DB - PRIME DP - Unbound Medicine ER -