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A twin study of polycystic ovary syndrome.
Fertil Steril 1995; 63(3):478-86FS

Abstract

OBJECTIVE

To examine the role of genetic and environmental factors in polycystic ovary syndrome (PCOS) by using the classic twin model.

SETTING

Outpatient clinic of the Royal Hospital for Women, Paddington, Sydney, New South Wales, Australia.

PATIENTS

A group of 19 monozygotic (MZ) and 15 dizygotic (DZ) twin pairs identified from the national twin register.

INTERVENTIONS

Ultrasound, clinical, and biochemical parameters were used to define PCOS.

RESULTS

Eleven pairs of twins (5 MZ, 6 DZ pairs) were scan-discordant (i.e., one twin had scan-PCOS and the co-twin did not). Model-fitting analysis suggested that fasting insulin level, androstanediol glucuronide, and body mass index (BMI) were significantly influenced by genetic factors.

CONCLUSION

This study suggests that PCOS is not the result of a single autosomal genetic defect, but rather environmental factors, perhaps both intrauterine and extrauterine, are involved in the pathogenesis of this disorder or that PCOS may be an X-linked disorder or the result of polygenic factors. However, fasting insulin level, androstanediol glucuronide, and BMI did appear to be under significant genetic influence.

Authors+Show Affiliations

Royal Hospital for Women, Paddington, New South Wales, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

7531655

Citation

Jahanfar, S, et al. "A Twin Study of Polycystic Ovary Syndrome." Fertility and Sterility, vol. 63, no. 3, 1995, pp. 478-86.
Jahanfar S, Eden JA, Warren P, et al. A twin study of polycystic ovary syndrome. Fertil Steril. 1995;63(3):478-86.
Jahanfar, S., Eden, J. A., Warren, P., Seppälä, M., & Nguyen, T. V. (1995). A twin study of polycystic ovary syndrome. Fertility and Sterility, 63(3), pp. 478-86.
Jahanfar S, et al. A Twin Study of Polycystic Ovary Syndrome. Fertil Steril. 1995;63(3):478-86. PubMed PMID: 7531655.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A twin study of polycystic ovary syndrome. AU - Jahanfar,S, AU - Eden,J A, AU - Warren,P, AU - Seppälä,M, AU - Nguyen,T V, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 478 EP - 86 JF - Fertility and sterility JO - Fertil. Steril. VL - 63 IS - 3 N2 - OBJECTIVE: To examine the role of genetic and environmental factors in polycystic ovary syndrome (PCOS) by using the classic twin model. SETTING: Outpatient clinic of the Royal Hospital for Women, Paddington, Sydney, New South Wales, Australia. PATIENTS: A group of 19 monozygotic (MZ) and 15 dizygotic (DZ) twin pairs identified from the national twin register. INTERVENTIONS: Ultrasound, clinical, and biochemical parameters were used to define PCOS. RESULTS: Eleven pairs of twins (5 MZ, 6 DZ pairs) were scan-discordant (i.e., one twin had scan-PCOS and the co-twin did not). Model-fitting analysis suggested that fasting insulin level, androstanediol glucuronide, and body mass index (BMI) were significantly influenced by genetic factors. CONCLUSION: This study suggests that PCOS is not the result of a single autosomal genetic defect, but rather environmental factors, perhaps both intrauterine and extrauterine, are involved in the pathogenesis of this disorder or that PCOS may be an X-linked disorder or the result of polygenic factors. However, fasting insulin level, androstanediol glucuronide, and BMI did appear to be under significant genetic influence. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/7531655/A_twin_study_of_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(16)57412-3 DB - PRIME DP - Unbound Medicine ER -