Tags

Type your tag names separated by a space and hit enter

Persistent hepatomegaly: an index of severity in sickle cell anaemia.
East Afr Med J. 1994 Nov; 71(11):742-4.EA

Abstract

Eighty sickle cell anaemia patients, 29 with persistent hepatomegaly and 51 without, were evaluated with respect to clinical severity score. Haemoglobin F (HbF) was also determined in 52 patients, 20 with persistent hepatomegaly and 32 without. The severity scores were computed from the steady state haematocrit, number of transfusions per year, and number of crises per year. The HbF level was determined by the alkali denaturation method. The patients with persistent hepatomegaly had significantly higher clinical severity scores (P < 0.001) and significantly lower levels of HbF (P < 0.0001). The implication of the finding is that patients with persistent hepatomegaly may have a more severe clinical course than those without, and clinicians managing them may have to pay more particular attention to them. In effect, persistent hepatomegaly may be a useful indicator of severity in sickle cell anaemia.

Authors+Show Affiliations

Department of Haematology, Faculty of Health Sciences, University of Ilorin, Nigeria.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7532125

Citation

Olatunji, P O., and A G. Falusi. "Persistent Hepatomegaly: an Index of Severity in Sickle Cell Anaemia." East African Medical Journal, vol. 71, no. 11, 1994, pp. 742-4.
Olatunji PO, Falusi AG. Persistent hepatomegaly: an index of severity in sickle cell anaemia. East Afr Med J. 1994;71(11):742-4.
Olatunji, P. O., & Falusi, A. G. (1994). Persistent hepatomegaly: an index of severity in sickle cell anaemia. East African Medical Journal, 71(11), 742-4.
Olatunji PO, Falusi AG. Persistent Hepatomegaly: an Index of Severity in Sickle Cell Anaemia. East Afr Med J. 1994;71(11):742-4. PubMed PMID: 7532125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Persistent hepatomegaly: an index of severity in sickle cell anaemia. AU - Olatunji,P O, AU - Falusi,A G, PY - 1994/11/1/pubmed PY - 1994/11/1/medline PY - 1994/11/1/entrez SP - 742 EP - 4 JF - East African medical journal JO - East Afr Med J VL - 71 IS - 11 N2 - Eighty sickle cell anaemia patients, 29 with persistent hepatomegaly and 51 without, were evaluated with respect to clinical severity score. Haemoglobin F (HbF) was also determined in 52 patients, 20 with persistent hepatomegaly and 32 without. The severity scores were computed from the steady state haematocrit, number of transfusions per year, and number of crises per year. The HbF level was determined by the alkali denaturation method. The patients with persistent hepatomegaly had significantly higher clinical severity scores (P < 0.001) and significantly lower levels of HbF (P < 0.0001). The implication of the finding is that patients with persistent hepatomegaly may have a more severe clinical course than those without, and clinicians managing them may have to pay more particular attention to them. In effect, persistent hepatomegaly may be a useful indicator of severity in sickle cell anaemia. SN - 0012-835X UR - https://www.unboundmedicine.com/medline/citation/7532125/Persistent_hepatomegaly:_an_index_of_severity_in_sickle_cell_anaemia_ DB - PRIME DP - Unbound Medicine ER -