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Preoperative cyst fluid analysis is useful for the differential diagnosis of cystic lesions of the pancreas.
Gastroenterology. 1995 Apr; 108(4):1230-5.G

Abstract

BACKGROUND/AIMS

It has been suggested that activity of pancreatic enzymes and concentrations of tumoral markers in cyst fluid may help to distinguish pseudocyst, serous, and mucinous cystadenomas. The aim of this study was to prospectively assess the reliability of preoperative biochemical and tumor marker analysis in cyst fluids obtained by fine-needle aspiration for pathological diagnosis.

METHODS

Cyst fluid was obtained preoperatively by fine-needle aspiration, and biochemical and tumoral marker values were measured. The diagnosis of cystic tumors (7 serous cystadenomas and 12 mucinous tumors) was established by surgical specimen analysis. Thirty-one pancreatic pseudocysts complicating well-documented chronic pancreatitis were also studied.

RESULTS

Carbohydrate antigen 19.9 levels of > 50,000 U/mL had a 75% sensitivity and a 90% specificity for distinguishing mucinous tumors from other cystic lesions. Carcinoembryonic antigen levels of < 5 ng/mL had a 100% sensitivity and an 86% specificity for distinguishing serous cystadenomas from other cystic lesions. Amylase levels of > 5000 U/mL had a 94% sensitivity and a 74% specificity for distinguishing pseudocysts from other cystic lesions.

CONCLUSIONS

High carbohydrate antigen 19.9, low carcinoembryonic antigen, and high amylase levels in cyst fluid are very indicative of mucinous tumors, serous cystadenomas, and pseudocysts, respectively.

Authors+Show Affiliations

Service de Gastroentérologie, Hôpital Beaujon, Clichy, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

7535275

Citation

Hammel, P, et al. "Preoperative Cyst Fluid Analysis Is Useful for the Differential Diagnosis of Cystic Lesions of the Pancreas." Gastroenterology, vol. 108, no. 4, 1995, pp. 1230-5.
Hammel P, Levy P, Voitot H, et al. Preoperative cyst fluid analysis is useful for the differential diagnosis of cystic lesions of the pancreas. Gastroenterology. 1995;108(4):1230-5.
Hammel, P., Levy, P., Voitot, H., Levy, M., Vilgrain, V., Zins, M., Flejou, J. F., Molas, G., Ruszniewski, P., & Bernades, P. (1995). Preoperative cyst fluid analysis is useful for the differential diagnosis of cystic lesions of the pancreas. Gastroenterology, 108(4), 1230-5.
Hammel P, et al. Preoperative Cyst Fluid Analysis Is Useful for the Differential Diagnosis of Cystic Lesions of the Pancreas. Gastroenterology. 1995;108(4):1230-5. PubMed PMID: 7535275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preoperative cyst fluid analysis is useful for the differential diagnosis of cystic lesions of the pancreas. AU - Hammel,P, AU - Levy,P, AU - Voitot,H, AU - Levy,M, AU - Vilgrain,V, AU - Zins,M, AU - Flejou,J F, AU - Molas,G, AU - Ruszniewski,P, AU - Bernades,P, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez SP - 1230 EP - 5 JF - Gastroenterology JO - Gastroenterology VL - 108 IS - 4 N2 - BACKGROUND/AIMS: It has been suggested that activity of pancreatic enzymes and concentrations of tumoral markers in cyst fluid may help to distinguish pseudocyst, serous, and mucinous cystadenomas. The aim of this study was to prospectively assess the reliability of preoperative biochemical and tumor marker analysis in cyst fluids obtained by fine-needle aspiration for pathological diagnosis. METHODS: Cyst fluid was obtained preoperatively by fine-needle aspiration, and biochemical and tumoral marker values were measured. The diagnosis of cystic tumors (7 serous cystadenomas and 12 mucinous tumors) was established by surgical specimen analysis. Thirty-one pancreatic pseudocysts complicating well-documented chronic pancreatitis were also studied. RESULTS: Carbohydrate antigen 19.9 levels of > 50,000 U/mL had a 75% sensitivity and a 90% specificity for distinguishing mucinous tumors from other cystic lesions. Carcinoembryonic antigen levels of < 5 ng/mL had a 100% sensitivity and an 86% specificity for distinguishing serous cystadenomas from other cystic lesions. Amylase levels of > 5000 U/mL had a 94% sensitivity and a 74% specificity for distinguishing pseudocysts from other cystic lesions. CONCLUSIONS: High carbohydrate antigen 19.9, low carcinoembryonic antigen, and high amylase levels in cyst fluid are very indicative of mucinous tumors, serous cystadenomas, and pseudocysts, respectively. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/7535275/Preoperative_cyst_fluid_analysis_is_useful_for_the_differential_diagnosis_of_cystic_lesions_of_the_pancreas_ DB - PRIME DP - Unbound Medicine ER -