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Vasectomy and prostate cancer: results from a multiethnic case-control study.
J Natl Cancer Inst 1995; 87(9):662-9JNCI

Abstract

BACKGROUND

Vasectomy, a widely used form of contraception, has been associated in some studies with increased prostate cancer risk.

PURPOSE

We assessed this association on the basis of data collected in a large multiethnic case-control study of prostate cancer that was conducted in the United States (Los Angeles, San Francisco, and Hawaii) and Canada (Toronto and Vancouver).

METHODS

In home interviews conducted with newly diagnosed prostate cancer case patients and population control subjects, we obtained information on the participants' medical history, including a history of vasectomy and the age at which the procedure was performed, as well as other potential risk factors. Blood samples were collected from control subjects only and were assayed for concentration of sex hormones and sex hormone-binding globulin.

RESULTS

The present analysis was based on 1642 prostate cancer patients and 1636 control subjects. A history of vasectomy was not significantly associated with prostate cancer risk among all racial/ethnic groups combined (odds ratio [OR] = 1.1; 95% confidence interval [CI] = 0.83-1.3), whites (OR = 0.94; 95% CI = 0.69-1.3), blacks (OR = 1.0; 95% CI = 0.59-1.8), or Chinese-Americans (OR = 0.96; 95% CI = 0.42-2.2). Among Japanese-Americans, the OR was 1.8 (95% CI = 0.97-3.4), but the statistically nonsignificant elevation in risk was limited to more educated men and those with localized cancers. ORs did not vary significantly by age at vasectomy or years since vasectomy. We found a lower serum concentration of sex hormone-binding globulin and a higher ratio of dihydrotestosterone to testosterone among vasectomized control subjects than among nonvasectomized control subjects.

CONCLUSIONS

The findings of this study do not support previous reports of increased prostate cancer risk associated with vasectomy. However, the altered endocrine profiles of vasectomized control subjects seen in this cross-sectional comparison warrant further evaluation in longitudinal studies.

Authors+Show Affiliations

Department of Health Research and Policy, Stanford University School of Medicine, Calif, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7538594

Citation

John, E M., et al. "Vasectomy and Prostate Cancer: Results From a Multiethnic Case-control Study." Journal of the National Cancer Institute, vol. 87, no. 9, 1995, pp. 662-9.
John EM, Whittemore AS, Wu AH, et al. Vasectomy and prostate cancer: results from a multiethnic case-control study. J Natl Cancer Inst. 1995;87(9):662-9.
John, E. M., Whittemore, A. S., Wu, A. H., Kolonel, L. N., Hislop, T. G., Howe, G. R., ... Teh, C. Z. (1995). Vasectomy and prostate cancer: results from a multiethnic case-control study. Journal of the National Cancer Institute, 87(9), pp. 662-9.
John EM, et al. Vasectomy and Prostate Cancer: Results From a Multiethnic Case-control Study. J Natl Cancer Inst. 1995 May 3;87(9):662-9. PubMed PMID: 7538594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vasectomy and prostate cancer: results from a multiethnic case-control study. A1 - John,E M, AU - Whittemore,A S, AU - Wu,A H, AU - Kolonel,L N, AU - Hislop,T G, AU - Howe,G R, AU - West,D W, AU - Hankin,J, AU - Dreon,D M, AU - Teh,C Z, PY - 1995/5/3/pubmed PY - 1995/5/3/medline PY - 1995/5/3/entrez KW - Americas KW - Biology KW - Canada KW - Cancer KW - Correlation Studies KW - Cultural Background KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Ethnic Groups KW - Family Planning KW - Genitalia KW - Genitalia, Male KW - Male Sterilization KW - Neoplasms KW - North America KW - Northern America KW - Physiology KW - Population KW - Population Characteristics KW - Prostate KW - Research Methodology KW - Risk Factors KW - Statistical Studies KW - Sterilization, Sexual KW - Studies KW - United States KW - Urogenital System KW - Vasectomy SP - 662 EP - 9 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 87 IS - 9 N2 - BACKGROUND: Vasectomy, a widely used form of contraception, has been associated in some studies with increased prostate cancer risk. PURPOSE: We assessed this association on the basis of data collected in a large multiethnic case-control study of prostate cancer that was conducted in the United States (Los Angeles, San Francisco, and Hawaii) and Canada (Toronto and Vancouver). METHODS: In home interviews conducted with newly diagnosed prostate cancer case patients and population control subjects, we obtained information on the participants' medical history, including a history of vasectomy and the age at which the procedure was performed, as well as other potential risk factors. Blood samples were collected from control subjects only and were assayed for concentration of sex hormones and sex hormone-binding globulin. RESULTS: The present analysis was based on 1642 prostate cancer patients and 1636 control subjects. A history of vasectomy was not significantly associated with prostate cancer risk among all racial/ethnic groups combined (odds ratio [OR] = 1.1; 95% confidence interval [CI] = 0.83-1.3), whites (OR = 0.94; 95% CI = 0.69-1.3), blacks (OR = 1.0; 95% CI = 0.59-1.8), or Chinese-Americans (OR = 0.96; 95% CI = 0.42-2.2). Among Japanese-Americans, the OR was 1.8 (95% CI = 0.97-3.4), but the statistically nonsignificant elevation in risk was limited to more educated men and those with localized cancers. ORs did not vary significantly by age at vasectomy or years since vasectomy. We found a lower serum concentration of sex hormone-binding globulin and a higher ratio of dihydrotestosterone to testosterone among vasectomized control subjects than among nonvasectomized control subjects. CONCLUSIONS: The findings of this study do not support previous reports of increased prostate cancer risk associated with vasectomy. However, the altered endocrine profiles of vasectomized control subjects seen in this cross-sectional comparison warrant further evaluation in longitudinal studies. SN - 0027-8874 UR - https://www.unboundmedicine.com/medline/citation/7538594/Vasectomy_and_prostate_cancer:_results_from_a_multiethnic_case_control_study_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/87.9.662 DB - PRIME DP - Unbound Medicine ER -