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Misplaced iron in kwashiorkor.

Abstract

OBJECTIVES

To determine the presence of radical promoting iron (non-protein-bound or loosely bound or free iron) in the plasma of children with kwashiorkor.

DESIGN

The bleomycin assay was employed for the quantitation of free or loosely bound iron.

SETTING

The Red Cross War Memorial Children's Hospital, Cape Town, Tertiary Care.

SUBJECTS

Fifty children on admission with kwashiorkor: six with marasmus and twelve healthy well-nourished controls.

RESULTS

Non-protein-bound iron was detected in the plasma of 58% of children with kwashiorkor but was absent in marasmic and healthy well-nourished children.

CONCLUSIONS

The presence of radical promoting iron supports the hypothesis that a free radical injury probably plays a role in the pathogenesis of kwashiorkor and its removal may improve mortality.

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Authors+Show Affiliations

,

Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.

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Source

MeSH

Bleomycin
Case-Control Studies
Child, Preschool
Humans
Infant
Iron
Kwashiorkor
Protein Binding
Protein-Energy Malnutrition

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7539742

Citation

Dempster, W S., et al. "Misplaced Iron in Kwashiorkor." European Journal of Clinical Nutrition, vol. 49, no. 3, 1995, pp. 208-10.
Dempster WS, Sive AA, Rosseau S, et al. Misplaced iron in kwashiorkor. Eur J Clin Nutr. 1995;49(3):208-10.
Dempster, W. S., Sive, A. A., Rosseau, S., Malan, H., & Heese, H. V. (1995). Misplaced iron in kwashiorkor. European Journal of Clinical Nutrition, 49(3), pp. 208-10.
Dempster WS, et al. Misplaced Iron in Kwashiorkor. Eur J Clin Nutr. 1995;49(3):208-10. PubMed PMID: 7539742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Misplaced iron in kwashiorkor. AU - Dempster,W S, AU - Sive,A A, AU - Rosseau,S, AU - Malan,H, AU - Heese,H V, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 208 EP - 10 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 49 IS - 3 N2 - OBJECTIVES: To determine the presence of radical promoting iron (non-protein-bound or loosely bound or free iron) in the plasma of children with kwashiorkor. DESIGN: The bleomycin assay was employed for the quantitation of free or loosely bound iron. SETTING: The Red Cross War Memorial Children's Hospital, Cape Town, Tertiary Care. SUBJECTS: Fifty children on admission with kwashiorkor: six with marasmus and twelve healthy well-nourished controls. RESULTS: Non-protein-bound iron was detected in the plasma of 58% of children with kwashiorkor but was absent in marasmic and healthy well-nourished children. CONCLUSIONS: The presence of radical promoting iron supports the hypothesis that a free radical injury probably plays a role in the pathogenesis of kwashiorkor and its removal may improve mortality. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/7539742/Misplaced_iron_in_kwashiorkor_ L2 - https://medlineplus.gov/iron.html DB - PRIME DP - Unbound Medicine ER -