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Circulating adhesion molecules during kidney allograft rejection.
Transplantation. 1995 Jun 27; 59(12):1695-9.T

Abstract

Adhesion molecules appear on leukocytes and endothelial cells mediating the localization and migration of leukocytes to sites of inflammation. Rejecting kidney grafts have shown an increased expression of these molecules. Recent reports have detected in serum soluble forms of adhesion molecules that could play a role in regulating inflammation. We have measured by ELISA the circulating serum levels of ICAM-1, VCAM-1 and E-selectin in: 23 controls, 33 chronic renal failure patients (CRF), 20 hemodialysis patients (HD), 17 samples from 6 patients with stable kidney graft function (STx), 25 samples from 8 patients with steroid-responsive rejection proven by biopsy, and 28 samples from 9 patients with steroid-resistant rejection and good response to OKT3. There was not a rise in cICAM-1 or cE-selectin levels during rejection compared with the steady phase before and after rejection. In the case of cVCAM-1, only the OKT3 group showed increased rejection levels (P < 0.05) that were maintained after rejection. For ICAM-1, CRF and HD groups had higher levels than the remaining groups. cVCAM-1 levels were elevated in all groups when compared with control, furthermore, OKT3 and HD groups had higher levels than the STx, CRF, or steroid-responsive groups. For cE-selectin, we only found differences between the CRF and both rejection groups. Serum creatinine correlated significantly with c-ICAM-1 and cVCAM-1 R = 0.30 and R = 0.22), but not with cE-selectin. We conclude that soluble adhesion molecules levels are not valuable markers for rejection. Patients with chronic renal failure have increased levels of adhesion molecules, which could reflect an impaired elimination.

Authors+Show Affiliations

Nephrology Services, University Hospital Marqués de Valdecilla, Santander, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7541576

Citation

Alcalde, G, et al. "Circulating Adhesion Molecules During Kidney Allograft Rejection." Transplantation, vol. 59, no. 12, 1995, pp. 1695-9.
Alcalde G, Merino J, Sanz S, et al. Circulating adhesion molecules during kidney allograft rejection. Transplantation. 1995;59(12):1695-9.
Alcalde, G., Merino, J., Sanz, S., Zubimendi, J. A., Ruiz, J. C., Torrijos, J., de Francisco, A. L., Cotorruelo, J. G., López-Hoyos, M., & Novo, M. J. (1995). Circulating adhesion molecules during kidney allograft rejection. Transplantation, 59(12), 1695-9.
Alcalde G, et al. Circulating Adhesion Molecules During Kidney Allograft Rejection. Transplantation. 1995 Jun 27;59(12):1695-9. PubMed PMID: 7541576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating adhesion molecules during kidney allograft rejection. A1 - Alcalde,G, AU - Merino,J, AU - Sanz,S, AU - Zubimendi,J A, AU - Ruiz,J C, AU - Torrijos,J, AU - de Francisco,A L, AU - Cotorruelo,J G, AU - López-Hoyos,M, AU - Novo,M J, PY - 1995/6/27/pubmed PY - 1995/6/27/medline PY - 1995/6/27/entrez SP - 1695 EP - 9 JF - Transplantation JO - Transplantation VL - 59 IS - 12 N2 - Adhesion molecules appear on leukocytes and endothelial cells mediating the localization and migration of leukocytes to sites of inflammation. Rejecting kidney grafts have shown an increased expression of these molecules. Recent reports have detected in serum soluble forms of adhesion molecules that could play a role in regulating inflammation. We have measured by ELISA the circulating serum levels of ICAM-1, VCAM-1 and E-selectin in: 23 controls, 33 chronic renal failure patients (CRF), 20 hemodialysis patients (HD), 17 samples from 6 patients with stable kidney graft function (STx), 25 samples from 8 patients with steroid-responsive rejection proven by biopsy, and 28 samples from 9 patients with steroid-resistant rejection and good response to OKT3. There was not a rise in cICAM-1 or cE-selectin levels during rejection compared with the steady phase before and after rejection. In the case of cVCAM-1, only the OKT3 group showed increased rejection levels (P < 0.05) that were maintained after rejection. For ICAM-1, CRF and HD groups had higher levels than the remaining groups. cVCAM-1 levels were elevated in all groups when compared with control, furthermore, OKT3 and HD groups had higher levels than the STx, CRF, or steroid-responsive groups. For cE-selectin, we only found differences between the CRF and both rejection groups. Serum creatinine correlated significantly with c-ICAM-1 and cVCAM-1 R = 0.30 and R = 0.22), but not with cE-selectin. We conclude that soluble adhesion molecules levels are not valuable markers for rejection. Patients with chronic renal failure have increased levels of adhesion molecules, which could reflect an impaired elimination. SN - 0041-1337 UR - https://www.unboundmedicine.com/medline/citation/7541576/Circulating_adhesion_molecules_during_kidney_allograft_rejection_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=7541576.ui DB - PRIME DP - Unbound Medicine ER -