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Soluble adhesion molecules and interleukin-2 receptor concentrations in patients with autoimmune chronic hepatitis.
Eur J Gastroenterol Hepatol 1995; 7(5):455-60EJ

Abstract

OBJECTIVE

To test the hypothesis that elevated serum levels of intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), (s)E-selectin, (s)P-selectin and soluble interleukin-2 receptor (sIL-2R) occur in patients with biochemically inactive autoimmune hepatitis (AICH) compared with controls. Such a finding would suggest continued immune activation, which in the long-term would contribute to the development of cirrhosis in such patients.

METHODS

sICAM-1, sVCAM-1, sE-selectin, sP-selectin and sIL-2R were measured in serum from 50 patients with AICH, divided into two groups according to whether their serum alanine aminotransferase (ALT) levels were normal (below 40 IU/l) or increased (above 40 IU/l). Fourteen healthy subjects served as controls. Eight patients were followed after the induction of remission with increased immunosuppressive therapy.

RESULTS

Elevated levels of sICAM-1, sVCAM-1 and sE-selectin were found in patients with AICH compared with controls, independent of their ALT concentration. Only sICAM-1 was significantly elevated in the patients with active disease compared with patients with inactive disease. sIL-2R concentrations were significantly higher in patients with active disease (ALT above 40 IU/l) compared with controls. sP-selectin concentrations were similar in controls and patients with AICH. In patients with clinical and biochemical relapse, increased steroid therapy was followed by a significant reduction in sICAM-1, sVCAM-1 and sIL-2R. The response of sE-selectin was more variable. sICAM-1 remained elevated in five of the eight patients treated with increased steroid therapy despite normalization of their transaminase levels, sIL-2R, sE-selectin and sVCAM-1 levels. In 52% of patients with biochemically inactive AICH (ALT below 40 IU/l), sICAM-1 was above the control range.

CONCLUSIONS

These data suggest that patients with AICH have ongoing immune activation despite biochemically inactive disease. This may result in low grade hepatic inflammation and may explain the progression to cirrhosis in patients with AICH despite immunosuppressive therapy.

Authors+Show Affiliations

Department of Medicine, University of Edinburgh, Royal Infirmary, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7542148

Citation

Simpson, K J., et al. "Soluble Adhesion Molecules and Interleukin-2 Receptor Concentrations in Patients With Autoimmune Chronic Hepatitis." European Journal of Gastroenterology & Hepatology, vol. 7, no. 5, 1995, pp. 455-60.
Simpson KJ, Jones AL, Forbes Howie A, et al. Soluble adhesion molecules and interleukin-2 receptor concentrations in patients with autoimmune chronic hepatitis. Eur J Gastroenterol Hepatol. 1995;7(5):455-60.
Simpson, K. J., Jones, A. L., Forbes Howie, A., & Hayes, P. C. (1995). Soluble adhesion molecules and interleukin-2 receptor concentrations in patients with autoimmune chronic hepatitis. European Journal of Gastroenterology & Hepatology, 7(5), pp. 455-60.
Simpson KJ, et al. Soluble Adhesion Molecules and Interleukin-2 Receptor Concentrations in Patients With Autoimmune Chronic Hepatitis. Eur J Gastroenterol Hepatol. 1995;7(5):455-60. PubMed PMID: 7542148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soluble adhesion molecules and interleukin-2 receptor concentrations in patients with autoimmune chronic hepatitis. AU - Simpson,K J, AU - Jones,A L, AU - Forbes Howie,A, AU - Hayes,P C, PY - 1995/5/1/pubmed PY - 1995/5/1/medline PY - 1995/5/1/entrez SP - 455 EP - 60 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 7 IS - 5 N2 - OBJECTIVE: To test the hypothesis that elevated serum levels of intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), (s)E-selectin, (s)P-selectin and soluble interleukin-2 receptor (sIL-2R) occur in patients with biochemically inactive autoimmune hepatitis (AICH) compared with controls. Such a finding would suggest continued immune activation, which in the long-term would contribute to the development of cirrhosis in such patients. METHODS: sICAM-1, sVCAM-1, sE-selectin, sP-selectin and sIL-2R were measured in serum from 50 patients with AICH, divided into two groups according to whether their serum alanine aminotransferase (ALT) levels were normal (below 40 IU/l) or increased (above 40 IU/l). Fourteen healthy subjects served as controls. Eight patients were followed after the induction of remission with increased immunosuppressive therapy. RESULTS: Elevated levels of sICAM-1, sVCAM-1 and sE-selectin were found in patients with AICH compared with controls, independent of their ALT concentration. Only sICAM-1 was significantly elevated in the patients with active disease compared with patients with inactive disease. sIL-2R concentrations were significantly higher in patients with active disease (ALT above 40 IU/l) compared with controls. sP-selectin concentrations were similar in controls and patients with AICH. In patients with clinical and biochemical relapse, increased steroid therapy was followed by a significant reduction in sICAM-1, sVCAM-1 and sIL-2R. The response of sE-selectin was more variable. sICAM-1 remained elevated in five of the eight patients treated with increased steroid therapy despite normalization of their transaminase levels, sIL-2R, sE-selectin and sVCAM-1 levels. In 52% of patients with biochemically inactive AICH (ALT below 40 IU/l), sICAM-1 was above the control range. CONCLUSIONS: These data suggest that patients with AICH have ongoing immune activation despite biochemically inactive disease. This may result in low grade hepatic inflammation and may explain the progression to cirrhosis in patients with AICH despite immunosuppressive therapy. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/7542148/Soluble_adhesion_molecules_and_interleukin_2_receptor_concentrations_in_patients_with_autoimmune_chronic_hepatitis_ L2 - http://www.diseaseinfosearch.org/result/678 DB - PRIME DP - Unbound Medicine ER -